Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Makerere University | OTHER |
| International Centre of Insect Physiology and Ecology (ICIPE) | OTHER |
| Mothers Against Malnutrition and Hunger | UNKNOWN |
Not provided
Not provided
Not provided
The goal of this randomized controlled trial is to assess whether edible insect-enriched school porridge has nutrition and health benefits for children aged 6-9 years in refugee communities in Uganda.
The main question the research aims to answer is: Does a daily serving of maize porridge enriched with yellow mealworm flour improve the gut health, growth, and micronutrient status of children in comparison to a standard maize porridge?
Participants will:
Consume a daily serving of yellow mealworm porridge or a maize porridge for one school term (3 months). Data is collected before, during and after the intervention period.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Yellow mealworm-enriched porridge | Experimental | Participants receive a daily meal of yellow mealworm-enriched porridge, served in schools. The porridge provides 420 Kcal/serving |
|
| Maize porridge | Other | Participants receive a standard maize porridge served in schools. This porridge is comparable to the porridge served in the parent-led school feeding program. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Insect porridge | Other | Yellow mealworm porridge |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in linear growth based on absolute height gain over 3 months intervention period | Assessing the effect of the intervention on height gain measured in cm | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in myeloperoxidase (MPO) over 3 months intervention period | Assessing the effect of the intervention on myeloperoxidase (ng/mL), which is a stool marker for Environmental Enteric Dysfunction (EED). A high value indicates high intestinal inflammation. | 3 months |
| Change in alpha-1-anti-trypsin (AAT) over 3 months intervention period |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Ezekiel Mupere, PhD, MD | Makerere University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kako and Bukere Primary School | Kyegegwa | Uganda |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Child and Family Health, Uganda |
| UNKNOWN |
| Research and Action for Income Security | UNKNOWN |
Two-arm randomized intervention
Not provided
Not provided
Data collectors assessing anthropometric measures, dietary records and questionnaires were masked
| Maize Porridge | Other | Maize porridge |
|
|
Assessing the effect of the intervention on alpha-1-anti-trypsin (mg/g) which is a stool marker for Enteric Environemtal Dysfunction ( EED). A high value indicates high intestinal protein loss. |
| 3 months |
| Change in in Neopterin (NEO) over the 3 months intervention period | Assessing the effect of the intervention on Neopterin ( nmol/L) which is a stool marker for Enteric Environemtal Dysfunction (EED). A high value indicates intestinal inflammation. | 3 months |
| Change in weight over the 3 months intervention period | Assessing the effect of the intervention on weight gain (kg) | 3 months |
| Change in BMI- for- age Z-score over 3 months intervention period | Assessing the effect of the intervention on BMI-for-age Z-score, by combining weight (Kg) and Height (m2) to report BMI (kg/m2) using the cut offs: Overweight: >+1SD, Obesity: >+2SD, Thinness: <-2SD, Severe thinness: <-3SD | 3 months |
| Change in Height- for-age Z-score over the 3 months intervention period | Assessing the effect of the intervention on height-for-age Z-score values using the cut offs: < -2 to -3 HAZ moderately stunted, HAZ < -3 severely stunted | 3 months |
| Change in Weight- for-age Z-score over the 3 months intervention period | Assessing the effect of the intervention on weight-for-age Z-score using the cut offs: -2 to-3 WAZ moderately underweight, WAZ < -3 severely underweight | 3 months |
| Change in Mid-Upper Arm Circumference (MUAC) over the 3 months intervention period | Assessing the effect of the intervention on the Mid-Upper Arm Circumference in cm using the cut-offs: <13.5cm severe acute malnutrition, 13.5cm -14.5cm moderate acute malnutrition. | 3 months |
| Change in Subscapular and Triceps skinfold thickness over 3 months intervention period | Assessing the effect of the intervention on subscapular and triceps skinfold thickness measured in mm. | 3 months |
| Change in waist circumference measurement over 3 months intervention period | Assessing the effect of the intervention on waist circumference measured in cm. | 3 months |
| Change in fat mass over the 3 months intervention period | Assessing the effect of the intervention on fat mass measured in kgs using deuterium dilution method and bioimpedance analyzer. Low fat mass indicates healthier body composition. | 3 months |
| Change in fat free mass over the 3 months intervention period | Assessing the effect of the intervention on fat free mass measured in kg using deuterium dilution method and bioimpedance analyzer. A high fat free mass indicates high muscle mass and healthier body composition. | 3 months |
| Change in fat mass index over the 3 months intervention period | Assessing the effect of the intervention on fat mass index measured in kg/m2, using deuterium dilution method and bioimpedance analyzer. Low fat mass index indicates a healthier body composition. | 3 months |
| Change in fat free mass index over 3 months intervention period | Assessing the effect of the intervention on fat free mass index ( FFMI) measured in kg/m2 using deuterium dilution method and bioimpedance analyzer. A high fat free mass index indicates high muscle mass and healthier body composition | 3 months |
| Change in C- reactive protein (CRP) over the 3 months intervention period | Assessing the effect of the intervention on C-reactive Protein(mg/L) which is a blood marker for systemic inflammation. High CRP values indicate systemic inflammation. | 3 months |
| Change in alpha-1-acid glycoprotein (AGP) over the 3 months intervention period | Assessing the effect of the intervention on alpha-1-acid glycoprotein (g/L) which is a blood marker for systemic inflammation. High AGP values indicate systemic inflammation. | 3 months |
| Change in insulin like growth factor (IGF-1) over the 3 months intervention period | Assessing the effect of the intervention on insulin like growth factor (ng/mL) which is a blood markers for growth. High IGF-1 values support growth. | 3 months |
| Change in hemoglobin over the 3 months intervention period | Assessing the effect of the intervention on hemoglobin measured in g/dL. Low hemoglobin levels indicate Anemia. | 3 months |
| Change in ferritin over the 3 months intervention period | Assessing the effect of the intervention on serum ferritin measured in μg/L. A low level of serum ferritin indicates Anemia. | 3 months |
| Change in soluble transferrin receptor (sTfR) over the 3 months intervention period | Assessing the effect of the intervention on soluble transferrin receptor measured in mg/L. A high level of sTfR is associated with Anemia. | 3 months |
| Change in cobalamin over the 3 months intervention period | Assessing the effect of the intervention on cobalamin measured in pmol/L. A low level of cobalamin is associated with Vitamin B12 deficiency. | 3 months |
| Change in retinol binding protein (RBP) over the 3 months intervention period | Assessing the effect of the intervention on serum retinol binding protein (RBP) measured in µmol/l. A low level of RBP is associated with Vitamin A deficiency. | 3 months |
| Change in methyl malonic acid (MMA) over the 3 months intervention period | Assessing the effect of the intervention on methyl malonic acid (MMA) measured in nmol/L. A high level of MMA indicates Vitamin B12 deficiency. | 3 months |
| Change in citrulline over the 3 months intervention period | Assessing the effect of the intervention on plasma citrulline measured in μmol/L. A low level of citrulline indicates impaired intestinal function. | 3 months |