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| Name | Class |
|---|---|
| Istituto Clinico Humanitas | OTHER |
| Istituto Europeo di Oncologia | OTHER |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS | OTHER |
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The study is a retrospective, observational and multicentric study. The study describes robotic segmentectomies performed in four referred centers, with the aim to assess the perioperative compilications of robotic segmentectomies compared to video-assisted thoracoscopic surgery (VATS) and open approach.
Minimally invasive techniques have been gradually replacing open approach in the treatment of lung cancer. Video-assisted thoracoscopic surgery (VATS) was the first procedure to be developed in the thoracic field and is the most widespread. It has been associated with decreased postoperative pain, shorter recovery, decreased inflammatory response and improved tolerance to chemotherapy.
What is limiting video-assisted thoracoscopic surgery (VATS) spread is the steep learning curve, difficulties and discomfort to operate, suboptimal view and rigid instrumentation. These problems have been partially overcome by the Robotic technique (RATS).
This study aims to compare the perioperative complications of robotic segmentectomies to VATS and open approaches.
In addition, The secondary aim of the study is to analyze the duration of surgery, mediastinal and hilar lymph nodes dissection, rate of conversion of robotic approach compared to VATS, overall survival and disease free survival in the three different approaches.
The study is retrospective, observational and multicentric. The four centers involved are: IRCCS San Raffaele Hospital, IRCCS European Institute of Oncology - IEO, IRCCS Humanitas Research Hospital - ICH and the department of General Thoracic Surgery, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
The population includes: all patients that underwent segmentectomies from the 1st January 2010 to the 31st of December 2023 treated with robotic segmentectomy and VATS or open segmentectomy, reaching a total of 472 cases of which 50 from our hospital.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case group : Robotic Approach | Patients with a pre or post-operative diagnosis of NSCLC surgically treated with robotic segmentectomy from 1st January 2010 to the 31st to December 2023 | ||
| Control group: video-assisted thoracoscopic surgery (VATS) and open | Patients with a pre or post-operative diagnosis of NSCLC surgically treated with video-assisted thoracoscopic surgery (VATS) and open segmentectomy from 1st January 2010 to the 31st to December 2023 |
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| Measure | Description | Time Frame |
|---|---|---|
| The perioperative complications of robotic approach | The investigators will measure the perioperative complications of robotic lung resection in patients with a pre or post-operative diagnosis of non-small cell lung cancer (NSCLC). Complications will be categorized according to the Clavien-Dindo scale. | from the surgery at 30-90 days after |
| The perioperative complication of video-assisted thoracoscopic surgery (VATS) approach | The investigators will measure the perioperative complications of video-assisted thoracoscopic surgery (VATS) appraoch in patients with a pre or post-operative diagnosis of non-small cell lung cancer (NSCLC). Complications will be categorized according to the Clavien-Dindo scale. | 30-90 days after surgery |
| The perioperative complications of the open approach | The investigators will measure the perioperative complications of open approach in patients with a pre or post-operative diagnosis of non-small cell lung cancer (NSCLC). Complications will be categorized according to the Clavien-Dindo scale. | 30-90 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of surgery | Duration of the surgery based on the approach measured in minutes | up to 1 month |
| Quality of lymphadenectomy | Number of lymphonodes station resected |
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Inclusion Criteria:
Exclusion Criteria:
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Patients that underwent segmentectomies from the 1st January 2010 to the 31st of December 2023 treated with robotic segmentectomy (case) and video-assisted thoracoscopic (VATS) or open segmentectomy (control)
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pierluigi Novellis, Medical Doctor | Contact | 0226437202 | +39 | novellis.pierluigi@hsr.it |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istituto Clinico Humanitas | Recruiting | Rozzano | Milan | 20089 | Italy |
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| ID | Term |
|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
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| up to 1 month |
| Conversion rate | Number of surgery procedures converted | up to 1 month |
| Survival analysis | Presence or absence of local and distant relapse | up to 5 years |
| Scientific Institute Ospedale San Raffaele | Recruiting | Milan | 20132 | Italy |
|
| Istituto Europeo di Oncologia | Recruiting | Milan | 20141 | Italy |
|
| Policlinico Universitario Agostino Gemelli | Recruiting | Rome | 30151 | Italy |
|
| D013899 |
| Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |