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| ID | Type | Description | Link |
|---|---|---|---|
| University of Aberdeen | Other Identifier | University of Aberdeen |
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Both sarcopenic obesity and chronic obstructive pulmonary diseases (COPD) are common conditions that mainly affect middle-aged and older adults. Previous research has shown that increased dietary intake of total and plant-based protein is associated with a lower risk of sarcopenic obesity, using data from the EPIC Norfolk study. Furthermore, a systematic review and meta-analysis showed that having sarcopenic obesity was associated with significantly impaired lung function outcomes. Other research has shown that increased intake of dietary protein leads to a better treatment outcome for respiratory diseases. The aim of this pilot observational study is to investigate, in more detail, the relationship between the quantity and source of dietary protein intake, the prevalence of sarcopenic obesity, and lung function, in a small cohort of older female participants with COPD. The study will also consider the role of inflammation in relation to sarcopenic obesity and lung function outcomes. This study will help to improve the understanding of the relationship between sarcopenic obesity and lung function outcomes, and how dietary protein intake and inflammation can affect this relationship and each of the outcomes.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| the relationship between the quantity and source of dietary protein intake, and the prevalence of sarcopenic obesity, and lung function outcomes | Other | Primary Objective The primary objective is to measure the relationship between the quantity and source of dietary protein intake, and the prevalence of sarcopenic obesity, and lung function outcomes, in older female participants with clinically diagnosed COPD. Secondary Objectives The secondary objective is to investigate whether the level of inflammation (plasma CRP) is associated with the intake of total, plant-based and animal-based protein, with the prevalence of sarcopenic obesity, and with lung function outcomes. |
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| Measure | Description | Time Frame |
|---|---|---|
| Association between dietary protein and the prevalence of sarcopenic obesity | Association between dietary intake of total, plant-based and animal-based protein and the prevalence of sarcopenic obesity. | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Association between dietary protein and lung functions outcomes | Association between dietary intake of total, plant-based and animal-based protein and lung functions outcomes (Forced Vital Capacity (FVC), Forced Expiratory Volume in The First Second(FEV1), and The Ratio of Forced Expiratory Volume in The First Second to Forced Vital Capacity (FEV1/FVC ratio)). | through study completion, an average of 1 year |
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Inclusion Criteria:
Exclusion Criteria:
Female with COPD aged 55 and over
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Women with clinically diagnosed COPD, from GP practices in Aberdeen,United Kingdom, through the Primary Care Research Network.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Baukje de Roos | Aberdeen | Scotland | AB25 2ZD | United Kingdom |
It is not yet known if there will be a plan to make IPD available.
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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A single blood sample will be taken by venepuncture (usually from the antecubital vein) by a trained phlebotomist, after at least 9 hours of fasting overnight. The blood sample will be collected into a heparin tube and spun (for 15 minutes at 2000 x g) to obtain plasma. Plasma samples will be stored at - 80°C until batch analysis of high-sensitivity C-reactive protein (hs-CRP) levels, using the Konelab Clinical Analyser at the Rowett Institute, the University of Aberdeen, Aberdeen, United Kingdom.
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |