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| Name | Class |
|---|---|
| Hospital de Sao Joao, Porto | UNKNOWN |
| RISE Study Group | NETWORK |
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This study aims to contribute to the identification of factors that may be predictive of cognitive function and to provide data on cerebral hemodynamic in ischemic and haemorrhagic stroke. This study will prospectively study cerebral autoregulation, neurovascular coupling and microembolic signs in cerebrovascular patients with ischemic and haemorrhagic stroke and its relationship with cognitive function and functional recovery
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ischemic Stroke (Carotid Circulation) | Patients with ischemic stroke of atherosclerotic, cardioembolic and embolic etiology from an unknown source |
| |
| Ischemic Stroke (Posterior Circulation) | Patients with ischemic stroke of atherosclerotic, cardioembolic and embolic etiology from an unknown source |
| |
| Haemorrhagic Stroke | Patients with intracerebral haemorrhages |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cerebral Autoregulation (CAR) | Diagnostic Test | Cerebral Autoregulation (CAR) is the mechanism capable of maintaining cerebral blood flow constant despite fluctuations in blood pressure. The evaluation of dynamic CAR (dCAR) with spontaneous blood pressure variations allows it to be applied in acute and non-collaborating patients |
| Measure | Description | Time Frame |
|---|---|---|
| Functional status | The modified Rankin Scale (mRS): 0 - None; 1- No significant disability despite symptoms: able to carry out all usual duties and activities; 2 - Slight disability: unable to carry out all previous activities, but able to look after own affairs without assistance; 3 - Moderate disability: requiring some help, but able to walk without assistance; 4 - Moderately severe disability: unable to walk without assistance, unable to attend to needs without assistance; 5 - Severe disability: bed-ridden, incontinent, and requiring constant nursing care and attention; 6 - Dead | 3±1 months after onset; 12±1 months after onset |
| Cognitive status | Cognitive status at 12 months of follow-up will be calculated based in 7-scale cognitive score operationalized from Montreal Cognitive Assessment (MoCA) together with modified Rankin Scale (mRS):
| 12±1 months after onset |
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Inclusion Criteria:
Exclusion Criteria:
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The study population includes participants who suffered a stroke admitted in the stroke unit (Centro Hospitalar Universitário de São João, Porto, Portugal), being included in order of admission. Provide signed and dated informed consent; more than 18 years; Patients with intracerebral haemorrhages; Patients with ischemic stroke of atherosclerotic, cardioembolic and embolic etiology from an unknown source.
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| Name | Affiliation | Role |
|---|---|---|
| Pedro Castro, PhD | Universidade do Porto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centro Hospitalar e Universitário de São João, EPE | Porto | Portugal |
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This is a prospective cohort study with inclusion of consecutive ischemic stroke patients. The assessment conducted on the included patients will consist of a cerebral transcranial Doppler evaluation, a cognitive screening, and questions regarding functional recovery and daily living activities.
|
| Neurovascular coupling (NVC) | Diagnostic Test | Neurovascular coupling (NVC) is the relationship between neural activity and cerebral blood flow, allowing this activity to be evaluated in spatiotemporal terms . |
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| Microembolic signals (MES) | Diagnostic Test | Microembolic signals (MES) |
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| Montreal Cognitive Assessment (MoCA) | Diagnostic Test | Montreal Cognitive Assessment (MoCA) |
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| Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) | Diagnostic Test | Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) |
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| Instrumental Activities of Daily Living Scale (IADL) | Diagnostic Test | Instrumental Activities of Daily Living Scale (IADL) |
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| Modified Rankin Scale for Neurologic Disability (mRS) | Diagnostic Test | Modified Rankin Scale for Neurologic Disability (mRS) |
|
| ID | Term |
|---|---|
| D020521 | Stroke |
| D000083242 | Ischemic Stroke |
| D000083302 | Hemorrhagic Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D000069336 | Neurovascular Coupling |
| ID | Term |
|---|---|
| D002560 | Cerebrovascular Circulation |
| D001775 | Blood Circulation |
| D002320 | Cardiovascular Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |
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