Randomized Control Trial of Sleeve Gastrectomy With Tirzepatide in Maximizing Weight Loss

Randomized Control Trial of Sleeve Gastrectomy With Tirzepatide in Maximizing Weight Loss

This study examines whether adding tirzepatide-a medication that helps with weight loss-after sleeve gastrectomy surgery can help people lose more weight after the surgery; better improve conditions like Type 2 diabetes, high blood pressure, high cholesterol, and sleep apnea after surgery and; whether this causes more complications or side effects compared to surgery alone.

Inclusion Criteria:

• Adult 18 to 65 years of age
• Body Mass Index >35 with comorbidity of Type 2 Diabetes and/or Hypertension and/or Hyperlipidemia and/or Obstructive Sleep Apnea OR Body Mass Index >40 with or without comorbidity
• Undergoing primary sleeve gastrectomy

Exclusion Criteria:

• Prior metabolic and bariatric surgery
• Prior use of GLP-1 agonist
• Prior history of pancreatitis
• Personal/family history of medullary thyroid cancer or MEN type 2
• Secondary cause of obesity
• Any eating disorder
• Pregnancy/lactation
• History of acute coronary syndrome or myocardial infarction
• History of stroke
• Hepatic dysfunction: AST/ALT >3 ULN
• Renal dysfunction eGFR<45ml/min/1.73m2
• Active malignancy
• History of diabetic retinopathy
• History of gastroparesis