the study aims to examine the short-term (30 days) effects of olive leaf extract on endothelial function in patients with acute coronary syndrome (ACS).

This investigation will be conducted on patients admitted to the emergency department for ACS. All participants will be screened and included within 24 hours post-ACS event and prior to discharge from the emergency department.

Inclusion Criteria:

Age over 18 years. Patients presenting with ST-segment alterations at rest, including ST elevation, with or without troponin elevation.

Patients who have not undergone surgery or have no additional primary percutaneous coronary intervention (P-PCI) planned within 8 weeks from the initial P-PCI.

Patients who provide informed consent. Patients available for and willing to adhere to follow-up procedures. Patients without significant cognitive impairment. Patients with a life expectancy of at least 2 years.

Exclusion Criteria:

• Severe LV hypertrophy (>15 mm);
• Patients with any evidence of inflammatory or malignant disease.
• Patient having valvular heart disease, pacemaker; cardiogenic shock
• Patient having any serious non-cardiac disease associated with a life expectancy <1 year
• Patients undergoing surgery within 30 days
• Patient having gastrointestinal disorder such as Crohn's disease