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Cavernous sinus syndrome (CSS) can be caused by a wide range of inflammatory, malignant, benign, vascular and miscellaneous disorders. Even after modern advances, reaching the final etiological diagnosis remains a challenge in CSS. This study is planned to determine the role and incremental value of 18F-FDG PET/CT in characterising different cavernous sinus pathologies based on their metabolic activity and detecting extracranial involvement.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment naive patients presenting with Cavernous Sinus Syndrome with cavernous sinus lesion on MRI |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| FDG radiotracer | Diagnostic Test | Pilot study evaluating the role of FDG PET/CT in Cavernous sinus syndrome |
|
| Measure | Description | Time Frame |
|---|---|---|
| SUVmax of the cavernous sinus lesions on FDG PET/CT | Standardized uptake value (SUV) will be calculated by drawing region of interest (ROI) in the cavernous sinus region both on the whole body and the dedicated brain image, while carefully excluding normal brain activity. If lesions in the bilateral cavernous sinuses will be present, SUVmax of both the lesions will be noted. | From enrollment to the establishment of final diagnosis upto a period of three months |
| Number of patients with extracranial sites of involvement on FDG PET/CT | From enrollment to the establishment of final diagnosis upto 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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All consecutive treatment naive patients of either sex with signs and symptoms of cavernous sinus syndrome attending the outpatient clinic in the Department of Neurology, Postgraduate Institute of medical Education & Research, Chandigarh.
Case definition for CSS- involvement of two or more cranial nerves (which pass through CS) or oculosympathetic fibers on the same side, or involvement of only cranial nerve in combination with a radiologically confirmed cavernous sinus lesion.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Post Graduate Institute of Medical Education and Research | Chandigarh | Chandigarh | 160012 | India |
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| ID | Term |
|---|---|
| D000096826 | Cavernous Sinus Syndromes |
| D009886 | Ophthalmoplegia |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D015835 | Ocular Motility Disorders |
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|
| D003389 | Cranial Nerve Diseases |
| D010243 | Paralysis |
| D009461 | Neurologic Manifestations |
| D005128 | Eye Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |