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How does magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) impact clinical prognosis in mesial temporal lobe epilepsy (mTLE)?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Open Surgery (anterior temporal lobectomy, ATL) | Experimental |
| |
| Minimally Invasive Surgery (MRgLITT) | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT) | Procedure | MRgLITT employs laser energy delivered through a stereotactically placed laser applicator to precisely ablate the epileptogenic tissue. |
| Measure | Description | Time Frame |
|---|---|---|
| Seizure freedom rate | According to International League Against Epilepsy [ILAE] Outcome Scale | 6-month, 1-year after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Seizure frequency | Times/Months | 6-month, 1-year after surgery |
| Seizure severity | National Hospital Seizure Severity Scale (NHS3) | 6-month, 1-year after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kai Zhang, Dr. | Contact | 86 01059975051 | zhangkai62035@sina.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Tiantan Hospital | Recruiting | Beijing | Beijing Municipality | 100070 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37800596 | Background | Mo J, Guo Z, Wang X, Zhang J, Hu W, Shao X, Sang L, Zheng Z, Zhang C, Zhang K. Magnetic resonance-guided laser interstitial thermal therapy vs. open surgery for drug-resistant mesial temporal lobe epilepsy: a propensity score matched retrospective cohort study. Int J Surg. 2024 Jan 1;110(1):306-314. doi: 10.1097/JS9.0000000000000811. |
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| ID | Term |
|---|---|
| D004833 | Epilepsy, Temporal Lobe |
| ID | Term |
|---|---|
| D004828 | Epilepsies, Partial |
| D004827 | Epilepsy |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D061887 | Conversion to Open Surgery |
| ID | Term |
|---|---|
| D004724 | Endoscopy |
| D019060 | Minimally Invasive Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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| Open Surgery | Procedure | Traditional Open Surgery |
|
| Cognitive function evaluation | Multiple Ability Self-Report Questionnaire (MASQ) | 6-month, 1-year after surgery |
| Memory function evaluation | Multifactorial Memory Questionnaire (MMQ) | 6-month, 1-year after surgery |
| Quality of life for epilepsy patients | EQ-5D-5L | 6-month, 1-year after surgery |
| Adverse events | percentage | within 7 days, 6-month, 1-year after surgery |
| Severe adverse events | percentage | within 7 days, 6-month, 1-year after surgery |
| Length of hospital stay | days | after surgery |
| Rate of antiepileptic drug reduction or withdrawn | percentage | 1-year after surgery |
| Rate of reoperations | percentage | 1-year after surgery |
| D009422 |
| Nervous System Diseases |
| D000073376 | Epileptic Syndromes |