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Probiotics combined with enteral nutrition reduces postoperative infectious complications in PD
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Probiotics combined with enteral nutrition reduces postoperative infectious complications in PD | Experimental | enteral nutrition+Pre-operative + one week post-operative Oral Bifidobacterium bifidum live triple capsule, 4 capsules Oral BID |
|
| Control group | No Intervention | Conventional postoperative treatment of the pancreas combined with enteral nutrition |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bifidobacterium Bifidum Oral Capsule | Drug | enteral nutrition+Pre-operative + one week post-operative Oral Bifidobacterium bifidum live triple capsule, 4 capsules Oral BID |
|
| Measure | Description | Time Frame |
|---|---|---|
| infectious complication | 1. Post-operative infections: Surgical site infections (SSI): including surgical incision infections and abdominal cavity infections. (1) incision infection: purulent secretions in the incision and culture of pathogenic bacteria (2) abdominal cavity infection: diagnosis can be made by meeting one of the following criteria: ①postoperative symptoms of systemic infection (fever > 38 ° C, white blood cell count higher than the upper limit of normal values), accompanied by abdominal distension, abdominal pain, and signs of peritonitis; ② abdominal drainage or puncture drainage fluid is purulent fluid, positive bacteriological culture results; ③ ultrasound, CT and other imaging tests or re-operation to confirm the presence of oozing or encapsulated abscess in the abdominal cavity; ③ ultrasound, CT and other imaging tests or re-operation to confirm the presence of oozing or encapsulated abscess. (iii) ultrasound or CT imaging or re-surgical confirmation of the presence of intra-abdominal ex | 30 days after surgery |
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Inclusion Criteria:
Exclusion Criteria:
. Current or recent (within the previous 1 month) use of probiotic-based products or antibiotic therapy medications.
Inability to tolerate PD due to cardiopulmonary function and other parameters
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fu XU FUXU | Contact | +86 182 0518 8516 | fuxunju2012@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 321 Zhongshan Road, Nanjing Gulou Hospital, Gulou District, Nanjing, Jiangsu Province, China | Recruiting | Nanjing | Jiangsu | 222000 | China |
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