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phenylketonuria (commonly known as PKU) is an inherited disorder that increases the levels of a substance called phenylalanine in the blood. PKU is usually associated with many metabolic complication including non-alcoholic fatty liver
this study will include PKU children sufferers 9n=40) with non-alcoholic fatty liver to be randomly assigned to group I (n=20) that will perform walking program (online supervised free walking that will be applied daily for eight weeks) or group II (N=20) that will act as waitlisted children
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group I | Experimental | this Group I will include PKU children sufferers (n=20) with non-alcoholic fatty liver that will perform walking program (online supervised free walking that will be applied daily for eight weeks) |
|
| Group II | No Intervention | this Group II will include PKU children sufferers (n=20) with non-alcoholic fatty liver that will act a waitlisted children |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| walking free online supervised program | Behavioral | this Group I will include PKU children sufferers (n=20) with non-alcoholic fatty liver that will perform walking program (online supervised free walking that will be applied daily for eight weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| alanine transamianse | it is a serum liver enzyme | it will be assessed after eight weeks |
| Measure | Description | Time Frame |
|---|---|---|
| aspartate tranaminase | it is a serum liver enzyme | it will be assessed after eight weeks |
| Gamma-glutamyl Transferase | it is a serum liver enzyme |
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Inclusion Criteria:
Exclusion Criteria:
self-representation of gender identity
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ali Isamil, Lecturer | Contact | 0201005154209 | ali.mohamed@pt.cu.edu.eg | |
| shimaaa bondok, PHD | Contact | 02 101 565 5118 | dr.shymaa_bondok@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Ali Ismail, lecturer | Cairo University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo University | Recruiting | Dokki | Giza Governorate | 11432 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41793924 | Derived | Ali Ismail AM, Gohary MM, Mabrouk Bondok SM, Abo Elatta AB, Ahmed El Gressy NSS, El Melhat AM, El-Sayed Felaya EE. Effect of walking exercise on liver enzymes in children with phenylketonuria and non-alcoholic fatty liver disease: A randomized controlled trial. Med Clin (Barc). 2026 Apr;166(4):107395. doi: 10.1016/j.medcli.2026.107395. Epub 2026 Mar 6. English, Spanish. |
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| ID | Term |
|---|---|
| D010661 | Phenylketonurias |
| D065626 | Non-alcoholic Fatty Liver Disease |
| ID | Term |
|---|---|
| D020739 | Brain Diseases, Metabolic, Inborn |
| D001928 | Brain Diseases, Metabolic |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| it will be assessed after eight weeks |
| alkaline phosphatase | it is a serum liver enzyme | it will be assessed after eight weeks |
| triglycerides | it will be measured in the serum | it will be assessed after eight weeks |
| body mass index | it will be measured after emptying bladder | it will be assessed after eight weeks |
| D009422 | Nervous System Diseases |
| D000592 | Amino Acid Metabolism, Inborn Errors |
| D008661 | Metabolism, Inborn Errors |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |