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| Name | Class |
|---|---|
| University of Sao Paulo | OTHER |
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The study aimed to investigate the effects of resistance training volume manipulation on whole muscle hypertrophy among non-responders and responders to a low resistance training dose (single-set).
The magnitude of muscle hypertrophy in response to resistance training (RT) is highly variable between individuals (response heterogeneity). Manipulations in RT variables may modulate RT-related response heterogeneity; yet, this remains to be determined.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single set | Experimental | One set of unilateral knee-extension exercise of 8-15 RM with a 60-90 s interval. |
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| Four sets | Experimental | Four sets of unilateral knee-extension exercise of 8-15 RM with a 60-90 s interval between sets. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lower body resistance training | Other | The RT protocol was performed using a unilateral knee-extension machine. To reduce potential sources of bias to exercise order, subjects alternated the starting leg for each training session. |
| Measure | Description | Time Frame |
|---|---|---|
| Quadriceps muscle cross-sectional area | Quadriceps muscle CSA was obtained through magnetic resonance imaging. | 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Maximum dynamic strength | Unilateral quadriceps 1-RM of both legs were assessed on a knee-extension machine | 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Dietary assessment | Dietary assemment using the USDA Automated Multiple-Pass Method | Before intervention |
| Mass spectrometry | Mass spectrometry metabolomics |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Sao Paulo | São Paulo | São Paulo | 05508-030 | Brazil |
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Lower body unilateral design
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| 10 weeks |
| Skeletal muscle RNA-sequencing | RNA sequencing using an Illumina NovaSeq Platform with a standard paired-end 150 bp (PE150) dual indexing protocol | 10 weeks |
| Muscle protein measures | Upstream binding factor (UBF) muscle protein was quantified by Simple Western capillary immunoassay. | 10 weeks |
| Muscle protein measures | v-Myc Avian Myelocytomatosis Viral Oncogene Homolog (c-Myc) muscle protein was quantified by Simple Western capillary immunoassay. | 10 weeks |
| Muscle protein measures | Frizzled class receptor 1 (Frizzled-1) muscle protein was quantified by Simple Western capillary immunoassay. | 10 weeks |
| Muscle protein measures | ribosomal protein L3 (rpL3) muscle protein was quantified by Simple Western capillary immunoassay. | 10 weeks |