Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Multispectral Optoacoustic Tomography (MSOT) is a promising imaging technology that utilizes pulsed laser light. One of the key capabilities of this technology is measuring oxygenation within human tissue. This proposed study aims to investigate possible limitations of human tissue used for reconstructive surgery due to flawed tissue perfusion.
Healthy volunteers as well as patients with a diagnosed head and neck cancer entity will be recruited. Both cohorts will then be scanned on different body areas (most common tissue sites used for reconstructive surgery on the back, arms and legs) to assess differences in muscle oxygenation between the healthy and tumor patient cohort using MSOT.
The hypothesis of the study is, that patients with diagnosed head and neck cancer entities are prone to compromised tissue perfusion due to a high prevalence of smoking within the head neck tumor patient cohort and therefore perfusion restirciting diseases e.g. peripheral arterial occlusive disease (PAOD).
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy | Healthy adult volunteers. Exclusion criteria: Chronical abuse of alcohol and nicotine, pregnancy and breastfeeding, ink / tattoo in the areas of interest (upper back, distal forearm, upper and lower leg) |
| |
| Head and neck cancer patients. | Patients with histopathological diagnosed head and neck cancer. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multispectral Optoacoustic Tomography (MSOT) | Device | Non-invasive transcutaneous MSOT imaging of muscle and subcutaneos regions. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Muscle oxygenation (in arbitrary units) | Oxygenated hemoglobin signal in the measured muscle regions in all different cohorts. | Immediately before and after intervention (exercise) within both cohorts. Within the cohort of head and neck tumor patients, possible postoperative second measurement of the transplanted tissue after performed reconstructive surgery. |
| Quantitative hemoglobin-associated signal (in arbitrary units) | Hemoglobin signal in the measured muscle regions in all different cohorts. | Immediately before and after intervention (exercise) within both cohorts. Within the cohort of head and neck tumor patients, possible postoperative second measurement of the transplanted tissue after performed reconstructive surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative compromise of microvascular free flaps (Microvascular revision, flap failure) | Correlation between preoperative accquired MSOT parameters (e.g. quantitative hemoglobin-associated signal, muscle oxygenation, oxygen saturation) in the head and neck cancer cohort and the clinical outcome of the reconstructive surgery (Microvascular revision, flap failure). | Postoperative observation of the free flap within the stationary visit until dismission (14 days) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Eligible subjects are Histopathological diagnosed head and neck tumor patients of the cmf department of the University clinic of erlangen (1) and healthy volunteers who will be recruited from advertised announcements (2).
All subjects meeting all inclusion and none of the exclusion criteria will be enrolled and added to their corresponding cohort (1 or 2).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Felix Wachter | Contact | +49 9131 85 41175 | felix.wachter@uk-erlangen.de | |
| Jonas Wolf, Dr. med. | Contact | +49 9131 85 43770 | jonas.wolf@uk-erlangen.de |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Erlangen | Recruiting | Erlangen | Bavaria | 91054 | Germany |
Due to the big amounts of acquired image data a publishing is not feasable.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
whole blood samples
| Oxygen saturation (in %) | Proportion of oxygenated hemoglobin signal compared with total hemoglobin signal in the measured muscle regions in all different cohorts | Immediately before and after intervention (exercise) within both cohorts. Within the cohort of head and neck tumor patients, possible postoperative second measurement of the transplanted tissue after performed reconstructive surgery. |
| Questionnaire items (Age, sex, height, weight, BMI, skin type, pre-existing conditions, medication, substance abuse [alcohol, nicotine], moderate physical activity per week) | Questionnaire items for both the healthy and the head and neck tumor cohort. | Once at the date of inclusion for the study. |
| Muscle oxygenation (in arbitrary units) | Oxygenated hemoglobin signal in the measured muscle regions in all different cohorts. | Immediately before and after intervention (exercise) within both cohorts. Within the cohort of head and neck tumor patients, possible postoperative second measurement of the transplanted tissue after performed reconstructive surgery. |
| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
Not provided
Not provided