Comparison of General Anesthesia Hemodynamics Between R and P in Patients Undergoing Laparoscopic Hepatectomy

Comparison of General Anesthesia Hemodynamics Between Remimazolam and Propofol in Patients Undergoing Laparoscopic Hepatectomy: a Randomized, Controlled Trial.

This study is a randomized controlled trial designed to investigate the effects of two anesthetics, remimazolam and propofol, on intraoperative hemodynamics in patients undergoing laparoscopic liver resection. The experimental group receives remimazolam, while the control group receives propofol. The primary objective is to compare the hemodynamic responses of patients in both groups during the surgical procedure, aiming to provide insights into the potential differences in cardiovascular stability and anesthetic management associated with these two drugs

Inclusion Criteria:

• Scheduled for LMH;
• Age 18-80 years, BMI 18-28 kg/m2;
• American Association of Anesthesiologists（ASA）I-III;
• Child-Pugh grade A or B;
• No serious heart, brain and other important organ lesions;
• Informed and consent, and signed informed consent.

Exclusion Criteria:

• ASA IV-V or Child-Pugh C;
• Left ventricular ejection fraction (EF) <30%;
• Implanted with temporary or permanent pacemakers;
• Organic heart disease;
• Uncontrolled hypertension, diabetes and other chronic diseases;
• Prolonged use of sedative and analgesic drugs (such as opioid analgesics, benzodiazepines, antianxiety, antidepressants, antipsychotics, etc.);
• Alcohol addiction;
• Allergic to benzodiazepines or propofol, or to any ingredient in the studied drug;
• Known history of allergy to other anesthetics; difficulty in airway and intubation during induction.