Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Sleep apnoea syndrome is a common disorder responsible for poor sleep quality and repeated oxygen depletion in the blood. Patients suffering from this disease experience a reduction in their endurance, i.e. their ability to make prolonged efforts. This loss of muscular endurance affects breathing in particular. It is known that poor sleep reduces endurance, but it is not knwon whether the repeated lack of oxygen for several hours at night also has this effect. This information could help improve the management of certain acute respiratory illnesses (asthma attacks, respiratory infections, etc.).
This project therefore seeks to establish a link between repeated oxygen deprivation and a reduction in the human brain's ability to train respiratory muscles. To this end, the healthy volunteers in this study will perform the same breathing exercise (breathing for as long as possible through a mask that makes inspiration difficult) twice: once after 6 hours' exposure to repeated oxygen deprivation, and once under conditions of normal oxygenation. The order of these exercises will be randomized. These exercises will take place in a special room, a hypoxia chamber, where it is possible to deplete the air breathed in oxygen.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Groupe 1 | Experimental | Control visit in normoxia at V1 and then test visit in intermittent hypoxia at V2 |
|
| Groupe 2 | Experimental | Test visit in intermittent hypoxia at V1 and then control visit in normoxia at V2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intermittent hypoxia | Other | Intermittent hypoxia during 6 hours in daytime |
|
| Measure | Description | Time Frame |
|---|---|---|
| To compare the inspiratory endurance of healthy volunteers after 6h of continuous breathing in room air and after 6h of continuous exposure to intermittent hypoxia in a hypoxic chamber. | through study completion, an average of 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| After 6 h of continuous breathing in room air and after 6 h of continuous exposure to intermittent hypoxia in a hypoxic chamber, compare Maximum Inspiratory Pressure (PImax) before and after the inspiratory endurance test. | through study completion, an average of 2 years | |
| Compare inspiratory cortical control measured by EEG over the first 15 and last 15 minutes of the inspiratory endurance test after 6 h of continuous breathing in room air and after 6 h of continuous exposure to intermittent hypoxia in a hypoxic chamber. |
| Measure | Description | Time Frame |
|---|---|---|
| To compare the somnolence of healthy volunteers after 6h of continuous breathing in room air and after 6h of continuous exposure to intermittent hypoxia in a hypoxic chamber. | Number of micro-sleep episodes of at least 3 seconds (stages N1, N2, N3, REM) identified in EEG tracings recorded under both conditions. | through study completion, an average of 2 years |
Inclusion Criteria:
Non-inclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Céline ABONNEAU | CHU Poitiers | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Poitiers | Poitiers | France | 86000 | France |
Not provided
| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Jun 11, 2025 | Jun 4, 2026 | Prot_000.pdf |
Not provided
Not provided
Not provided
Not provided
Not provided
| Normoxia | Other | Normoxia during 6 hours in daytime |
|
The inspiratory cortical control is recorded by electroencephalography to measure the amplitude of inspiratory premotor potentials in µV |
| through study completion, an average of 2 years |
| Compare respiratory discomfort with a visual analog scale at the start of the endurance test after 6 h of continuous breathing in room air and after 6 h of continuous exposure to intermittent hypoxia in a hypoxic chamber. | The visual analogue scale ranges from 0 to 10, with 10 being the most severe discomfort | through study completion, an average of 2 years |
| Compare the time to onset of respiratory discomfort in the inspiratory endurance test with a visual analog scale after 6 h of continuous breathing in room air and after 6 h of continuous exposure to intermittent hypoxia in a hypoxic chamber. | The visual analogue scale ranges from 0 to 10, with 10 being the most severe discomfort. The time to onset of respiratory discomfort is defined by the time it takes to reach 80% of the maximum discomfort declared by the volunteer. | through study completion, an average of 2 years |
| Compare sensory perception of inspiratory effort after 6 h of continuous breathing in room air and after 6 h of continuous exposure to intermittent hypoxia in a hypoxic chamber. | through study completion, an average of 2 years |
| Compare the quantity and phenotype of circulating microvesicles in ambient air or in intermittent hypoxia. | through study completion, an average of 2 years |
| Compare systolic pulmonary artery pressure in room air or intermittent hypoxia using trans-thoracic echography. | The systolic pulmonary artery pressure is measured by the following measurements :
| through study completion, an average of 2 years |
| Compare echographic signs of right ventricular function in room air or intermittent hypoxia using trans-thoracic echography. | Right ventricular function is estimated by measuring the tricuspid annular plane systolic excursion (TAPSE) and the S wave. | through study completion, an average of 2 years |