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assement of interleukin 23 in serum of patients with systemic lupus erythematosus related interstial lung disease .
for all patients detailed history taken clinical and rhumatological examination will be assessed and SLEDAI score will be collected from the case record of the patients&laboratory investigation included 1_erythrocytic sedimentation rate.2_complete blood count.3_interleukin23 .4_complement 3&4.5_Antinuclear Antibodies.6_Anti double stranded antibodies.7_full basic biochemical test(24 urine protien)8_high resolution computed tomography.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group 1 | Active Comparator | Patients with systemic lupus erythematosus without interstial lung disease. |
|
| group2 | Active Comparator | Patients with systemic lupus erythematosus with interstial lung disease. |
|
| group3 | Active Comparator | healthy control groups |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| interleukin 23 | Biological | assessment of interleukin 23 in Sera of patients using ELIZA |
|
| Measure | Description | Time Frame |
|---|---|---|
| interleukin 23 | level of interleukin 23 in Sera of patients with systemic lupus erythematosus using ELIZA | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Khadiga M Salem, resident doctor | Contact | 01069152448 | khadiga_mahmoud_post@med.sohag.edu.eg |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag university hospital | Recruiting | Sohag | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20467470 | Background | Yap DY, Lai KN. Cytokines and their roles in the pathogenesis of systemic lupus erythematosus: from basics to recent advances. J Biomed Biotechnol. 2010;2010:365083. doi: 10.1155/2010/365083. Epub 2010 May 6. | |
| 36698375 | Background | Haroon MM, Hegazy GA, Hassanien MA, Shaker O, Hussein WH. Significance of Interleukin 23 in Systemic Lupus Patients: Relation to Disease Activity and Damage Indices. Biologics. 2023 Jan 18;17:1-9. doi: 10.2147/BTT.S389021. eCollection 2023. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 10, 2026 | |
| Reset | Jun 4, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 10, 2026 | Jun 4, 2026 |
| ID | Term |
|---|---|
| D053759 | Interleukin-23 |
| ID | Term |
|---|---|
| D007378 | Interleukins |
| D016207 | Cytokines |
| D036341 | Intercellular Signaling Peptides and Proteins |
| D010455 | Peptides |
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| Sohag university | Recruiting | Sohag | Egypt |
|
| 37685766 | Background | Sisto M, Lisi S. Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries. J Clin Med. 2023 Sep 1;12(17):5699. doi: 10.3390/jcm12175699. |
| 34524907 | Background | Senoo S, Taniguchi A, Itano J, Oda N, Morichika D, Fujii U, Guo L, Sunami R, Kanehiro A, Tokioka F, Yoshimura A, Kiura K, Maeda Y, Miyahara N. Essential role of IL-23 in the development of acute exacerbation of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2021 Nov 1;321(5):L925-L940. doi: 10.1152/ajplung.00582.2020. Epub 2021 Sep 15. |
| D000602 |
| Amino Acids, Peptides, and Proteins |
| D011506 | Proteins |
| D001685 | Biological Factors |