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This study aims to investigate the efficacy of intraoperative intravenous lidocaine infusion on postoperative pain management and recovery in pediatric patients undergoing thoracoscopic pulmonary resection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lidocaine group | Experimental | Anesthesia induction is performed according to the standard protocol. Monitoring includes electrocardiography, pulse oximetry, arterial blood pressure, depth of anesthesia (Patient State Index, PSI), and pain score (Analgesia Nociception Index). In the lidocaine group, a single bolus dose of lidocaine 1.5 mg/kg is administered concurrently with the induction of anesthesia, followed by a continuous infusion of lidocaine at a rate of 1.5 mg/kg/hr. |
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| Control group | Placebo Comparator | The control group receives a continuous infusion of normal saline in the same volume as that administered to the lidocaine group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lidocaine (drug) | Drug | a single bolus dose of lidocaine 1.5 mg/kg is administered concurrently with the induction of anesthesia, followed by a continuous infusion of lidocaine at a rate of 1.5 mg/kg/hr. |
| Measure | Description | Time Frame |
|---|---|---|
| FLACC (ace, Legs, Activity, Cry, Consolability scale) Score | Highest FLACC Score recorded in the postanesthesia care unit (The scale is scored in a range of 0-10 with 0 representing no pain.) | up to 1 hour after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Remifentanil dose | Total amount of remifentanil administered during surgery | throughout surgery (up to 3 hours) |
| ANI (Analgesia Nociception Index) | ANI (Analgesia Nociception Index) values during surgery (scale ranging from 0 (indicating maximum pain) to 100 (indicating no pain)) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ji-Hyun Lee, MD, PhD | Contact | 82-2-2072-3661 | muslab6@snu.ac.kr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Recruiting | Seoul | 03080 | South Korea |
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| Saline infusion (placebo) | Drug | Continuous infusion of normal saline in the same volume as that administered to the lidocaine group. |
|
| throughout surgery (up to 3 hours) |
| FLACC scores | FLACC scores at 6 hours, 12 hours, and 24 hours postoperatively | 6 hours, 12 hours, and 24 hours postoperatively |
| Total analgesic dosage administered postoperatively | up to 3 days after surgery |
| Postoperative complications | until discharge (up to 3-4 days after surgery) |
| ID | Term |
|---|---|
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D008012 | Lidocaine |
| D004364 | Pharmaceutical Preparations |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
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