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The study aims to evaluate whether preoperative albumin supplementation in pediatric patients with hypoalbuminemia undergoing cardiac surgery can reduce inflammatory responses and prevent acute kidney injury (AKI) following cardiopulmonary bypass.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Albumin group | Experimental | A 20% albumin solution is administered over a period of one hour, starting at the time of anesthesia induction. | |
| Control group | Placebo Comparator | The same volume of crystalloid solution as the administered albumin is infused. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Albumin solution | Drug | A 20% albumin solution is administered over one hour starting from the induction of anesthesia, using the following formula: (4.0-preoperative serum albumin (g/dL))×plasma volume (kg×0.65-0.8 dL) |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of acute kidney injury (AKI) | The difference in the incidence of acute kidney injury (AKI) between groups, as measured by the KDIGO criteria | assessed up to postoperative day 7 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ji-Hyun Lee | Contact | 82-2-2072-3661 | muslab6@snu.ac.kr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Recruiting | Seoul | Seoul | 03080 | South Korea |
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| Crystalloid solutions | Drug | The same volume of crystalloid solution as the administered albumin is infused. |
| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
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| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| ID | Term |
|---|---|
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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