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Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is one of the top 10 causes of mortality worldwide. It is estimated that in 2017, 10 million people were infected with TB, and 1.6 million died from the disease, including 0.3 million people with human immunodeficiency virus (HIV) infection . TB remains the primary killer of HIV-positive individuals. TB incidence is falling at about 2% per year . Airborne transmission of M. tuberculosis typically causes TB infection in both immunocompetent and immunocompromised hosts and the disease is symptomatic and contagious .
TB and HIV infections are strictly linked together. TB is the most common opportunistic infection and causes high morbidity rate among people living with HIV. Because of the decrease in cell-mediated immunity, HIV alters the pathogenesis of TB, thereby expressively increasing the risk of TB in HIV-positive patients and eventually leading to more severe complications and forms of TB.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| P24 antigens and antibody | Diagnostic Test | estimation of antigens and antibodies to diagnose HIV | ||
| zeihl - Nelsen stain | Diagnostic Test | staining sputum from patients with HIV to detect tubercle bacilli | ||
| culture on Lowenstein jensen media | Diagnostic Test | spenciem will be inoculated on LJ media and kept for 2-8 weeks, to see small white colonies | ||
| Molecular detection of antibiotic resistance | Diagnostic Test | to see the pattern of antibiotic resistance of tubercle bacilli |
| Measure | Description | Time Frame |
|---|---|---|
| The Prevalance of tubercuolsis in immunocompetent patients suffereing from chronic chest problems | Patients suffering from chronic chest problems will be screened for presence of TB bacilli using chest X-ray, sputum smear, culture on LJ media, detection of DNA of TB bacilli using PCR | December 2024- June 2025 |
| The prevalence of tuberculosis in HIV patients | Detection of tubercle bacilli in HIV positive patients , these patients will be screened for presence of TB bacilli using chest X-ray, sputum smear, culture on LJ media, detection of DNA of TB bacilli using PCR | December 2024- June 2025 |
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This prospective study will be conducted on 100-200 patients with pulmonary and extra pulmonary TB attending Sohag University Hospital during the period from September 2024 to August 2025
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Noha S Shafik, Lecturer | Contact | 0201067261504 | Nohasaber@med.sohag.edu.eg | |
| Mona Lecturer | Contact |
| Name | Affiliation | Role |
|---|---|---|
| Noha S Shafik, Lecturer | Sohag university, Faculty of medicine | Principal Investigator |
| Asmaa T Mostafa, Lecturer | Sohag university, Faculty of Medicine | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of medicine | Sohag | 54345 | Egypt |
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| ID | Term |
|---|---|
| D014376 | Tuberculosis |
| ID | Term |
|---|---|
| D009164 | Mycobacterium Infections |
| D000193 | Actinomycetales Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
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| Ebtisam M Gad, Lecturer |
| Sohag university, Faculty of Medicine |
| Study Chair |
| Mona M Abdelrahman, Lecturer | Sohag university, Faculty of Medicine | Study Chair |
| Dina H Mohamed, Lecturer | Sohag university, Faculty of medicine | Study Chair |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |