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| ID | Type | Description | Link |
|---|---|---|---|
| ChiCTR | Registry Identifier | ChiCTR2400091276 |
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The goal of this clinical trial is to evaluate whether mivacurium chloride and succinylcholine can provide effective and safe muscle relaxation in adult patients aged 18-60 years undergoing bronchoscopy who require muscle relaxants during anesthesia. The main questions it aims to answer are:
Participants will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| mivacurium chloride | Experimental | mivacurium chloride 0.14 mg/kg induction bolus + 0.5 mg/kg/h maintenance infusion |
|
| succinylcholine | Active Comparator | succinylcholine (1 mg/kg induction bolus + 5 mg/kg/h maintenance infusion) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| mivacurium chloride | Drug | mivacurium chloride 0.14 mg/kg induction bolus + 0.5 mg/kg/h maintenance infusion |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of spontaneous breathing recovery | The rate of spontaneous breathing recovery after discontinuation of mivacurium chloride and succinylcholine during bronchoscopy. | Within 15 minutes after the completion of bronchoscopy. |
| Measure | Description | Time Frame |
|---|---|---|
| Recovery time of spontaneous breathing | Comparison of recovery times (minutes) for spontaneous breathing between mivacurium chloride and succinylcholine groups. Spontaneous breathing recovery is defined as achieving a tidal volume of 5 ml/kg and a respiratory rate of 12 breaths per minute. | From the end of bronchoscopy until spontaneous breathing, assessed up to 15 minutes post-procedure. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Peng Liang | Contact | 18980608961 | liangpengwch@scu.edu.cn |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41566470 | Derived | Zhang X, Xu Y, Li J, Xi Y, Xu Z, Liang P. Effect and safety of mivacurium chloride and succinylcholine for bronchoscopy: study protocol for a single-center, randomized, non-inferiority, and positive-controlled clinical trial. Trials. 2026 Jan 22;27(1):137. doi: 10.1186/s13063-026-09463-3. |
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| ID | Term |
|---|---|
| D009123 | Muscle Hypotonia |
| ID | Term |
|---|---|
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077590 | Mivacurium |
| D013390 | Succinylcholine |
| ID | Term |
|---|---|
| D007546 | Isoquinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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| succinylcholine | Drug | succinylcholine (1 mg/kg induction bolus + 5 mg/kg/h maintenance infusion) |
|
| Recovery time of consciousness | Comparison of recovery times (minutes) for consciousness recovery. Consciousness recovery is defined as the ability to open eyes upon verbal command or when called by name. | From the end of bronchoscopy until each specific recovery milestone is achieved, assessed up to 15 minutes post-procedure. |
| Laryngeal mask airway (LMA) removal time | Comparison of time to remove laryngeal mask airway (LMA) between mivacurium chloride and succinylcholine groups. | From the end of bronchoscopy until each specific recovery milestone is achieved, assessed up to 15 minutes post-procedure. |
| Mean pulse pressure at different stages | Blood pressure measurements should be taken at 1-minute intervals during the induction phase (pre-LMA insertion), until the LMA is inserted. For the pre-induction phase, post-LMA insertion, surgery start, surgery end, and post-LMA removal, blood pressure should be measured every 3 minutes, with recordings taken for a total of 3 minutes at each stage. The average blood pressure (mmHg) for each stage was calculated using the values recorded during that stage for both the mivacurium chloride and succinylcholine groups. | 3 minutes before induction, 1-minute intervals during induction until the LMA is inserted, 3 minutes after LMA insertion, 3 minutes after surgery start, 3 minutes after surgery end, and 3 minutes after LMA removal. |
| Oxygen saturation (%) recorded at different stages | Oxygen saturation (%) recorded for both mivacurium chloride and succinylcholine groups at different stages. | 3 minutes before induction, 1-minute intervals during induction until the LMA is inserted, 3 minutes after LMA insertion, 3 minutes after surgery start, 3 minutes after surgery end, and 3 minutes after LMA removal. |
| Heart rate recorded at different stages | Heart rate recorded (beats per minute) at different stages for both mivacurium chloride and succinylcholine groups. | 3 minutes before induction, 1-minute intervals during induction until the LMA is inserted, 3 minutes after LMA insertion, 3 minutes after surgery start, 3 minutes after surgery end, and 3 minutes after LMA removal. |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002794 | Choline |
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D013386 | Succinates |
| D003998 | Dicarboxylic Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009861 | Onium Compounds |