APPI-Cost Trial for Perforated Appendicitis

The APPI-Cost Trial: Cost Assessment of Povidone-Iodine Irrigation for Prevention of Intra-abdominal Abscess in Perforated Appendicitis

The purpose of this study to assess the clinical effectiveness and cost-effectiveness of povidone-iodine (PVI) irrigation in perforated appendicitis, to investigate barriers and facilitators to future implementation of PVI irrigation, and to collect costs and clinical and patient-reported outcomes among patients with non-perforated appendicitis.

Eligibility for Enrollment

Inclusion Criteria:

• Plan to undergo appendectomy for acute appendicitis

Exclusion Criteria:

• Preoperative hemodynamic instability requiring ongoing infusion of vasopressors
• Allergy to iodine
• Uncontrolled hyper- or hypothyroidism
• Renal dysfunction
• Pregnant or breastfeeding
• Primary language neither English nor Spanish
• Lack of functioning telephone or email account
• Incarcerated or in police custody

Eligibility for Randomization

Inclusion Criteria:

• Enrolled in study preoperatively
• Intraoperative diagnosis of perforated appendicitis

Exclusion Criteria:

• Non-perforated appendicitis