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| Name | Class |
|---|---|
| Ganzhou City People's Hospital | OTHER |
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This study will conduct a single-center clinical trial to explore the initial therapeutic effect of ginkgo biloba dropping pills, huperzine A injection and median nerve electrical stimulation in patients with cognitive impairment.
Specific experimental research methods were randomized, controlled, single-center, exploratory clinical study, through the treatment of ginkgo biloba dropping pills, huperzine A injection and median nerve electrical stimulation in patients with cognitive impairment, to observe the effects of their neuroprotection and cognitive function improvement.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Median nerve electrical stimulation group | Experimental | The optimal median nerve electrical stimulation treatment was given |
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| Huperzine A injection + median nerve electrical stimulation group | Experimental | Huperzine A injection can be administered before median nerve electrical stimulation to improve the therapeutic effect of electrical stimulation. Huperzine A injection: intramuscular injection, 1ml,0.2mg once a day, the course of treatment was 7 days. |
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| Huperzine A injection + median nerve electrical stimulation + Ginkgo leaf dropping pill group | Experimental | Huperzine A injection can be administered before median nerve electrical stimulation to improve the therapeutic effect of electrical stimulation. After the end of the electrical stimulation treatment, ginkgo biloba dropping pills were given as long-term administration to maintain the therapeutic effect. Huperzine A injection: intramuscular injection, 1ml,0.2mg once a day, the course of treatment was 7 days. Ginkgo leaf dropping pills: Oral, each pill weighs 63mg, 5 pills/time, 3 times/day, the course of treatment is 3 months. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Median nerve electrical stimulation treatment | Other | Median nerve electrical stimulation is an electrical stimulation therapy in which the electrode is placed at the median nerve point 2cm above the carpal wrinkles on the palmar surface of the wrist joint. Generally, the right median nerve is used for electrical stimulation. Electrical stimulation improves cognitive function by stimulating neurons in the brain and improving information transmission between neurons. When electrical current stimulates the brain, it can increase the activity level of neurons and promote the signal transmission between neurons. Its mechanism of action includes the regulation of neurotransmitter acetylcholine, thereby enhancing cognitive function. |
| Measure | Description | Time Frame |
|---|---|---|
| to assess the MMSE score | baseline，Day10，Day90 |
| Measure | Description | Time Frame |
|---|---|---|
| to assess the MoCA score | baseline，Day10，Day90 | |
| to assess the ADAS-cog score | baseline，Day10，Day90 | |
| to assess the HAMD score |
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Inclusion Criteria:
Be over 18 years old
Residual cognitive impairment due to brain injury
Exclusion Criteria:
The patient had severe underlying disease and unstable vital signs
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dong Wang | Contact | 18007076858 | 2623693068@qq.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Ganzhou City People's Hospital | Recruiting | Ganzhou | Jiangxi | 8112320 | China |
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| Huperzine A injection | Drug | intramuscular |
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| Ginkgo leaf dropping pill | Drug | oral |
|
| baseline，Day10，Day90 |
| to assess the HAMA score | baseline，Day10，Day90 |
| ID | Term |
|---|---|
| C050426 | huperzine A |
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