• Detachable String Magnetically Controlled Capsule Endoscopy for Patients with AUGIB

  NCT06725056

  Not yet recruitingInterventionalNot ApplicableUpdated Dec 10, 2024
• An Observer Blinded Comparison of MACE and Conventional Upper Gastrointestinal Endoscopy in Upper GI Bleeding

  NCT02690376

  CompletedInterventionalNot ApplicableUpdated Sep 23, 2019
• the MCCE vs EGD Trial

  NCT07004530

  Not yet recruitingInterventionalNot ApplicableUpdated Jun 4, 2025
• Detachable String Magnetically Controlled Capsule Endoscopy for Follow-up of Patients With Esophageal Diseases

  NCT05469152

  Unknown statusInterventionalNot ApplicableUpdated Jul 21, 2022
• Magnetic-controlled Capsule Endoscopy vs. Gastroscopy for Detection of Gastric Diseases

  NCT02219529

  CompletedInterventionalPhase 3Updated Jul 21, 2015
• Magnetically Controlled Capsule Endoscopy First vs. Standard Algorithm in Patients With Melena

  NCT04019067

  WithdrawnInterventionalNot ApplicableUpdated Sep 29, 2020

ClinicalTrials.gov ID

NCT06698874

Lead Sponsor

Changhai HospitalOTHER

Overall Status

Not yet recruiting

Study Type

Interventional

Phase

Not Applicable

Enrollment

204Estimated

Last Update Posted

Nov 21, 2024Actual

Start Date

Dec 1, 2024Estimated

Primary Completion Date

Aug 31, 2026Estimated

Completion Date

Dec 30, 2026Estimated

Official Title

Diagnostic Efficacy of Magnetically Controlled Capsule Endoscopy (MCE) for Identification of Bleeding Lesions in Patients with Antiplatelet Drugs-Related Acute Non-Hematochezia Gastrointestinal Bleeding：Prospective, Multicenter Study

Brief Summary

The goal of this clinical trial is to explore the diagnostic efficacy of detachable string magnetically controlled capsule endoscopy (ds-MCE) for identification of bleeding lesions in patients with antiplatelet drugs-related acute non-hematochezia gastrointestinal bleeding. The main questions it aims to answer are:

Compared to the conventional esophagogastroduodenoscopy, does ds-MCE accurately detect bleeding lesions in the upper gastrointestinal tract in patients with antiplatelet drugs-related acute non-hematochezia gastrointestinal bleeding? Recording bleeding lesions in the small bowel detected by ds-MCE in patients with antiplatelet drugs-related acute non-hematochezia gastrointestinal bleeding.

Participants will:

Undergo ds-MCE first and subsequently EGD within 24 hours. Receive follow-up in the following 30days.

Detailed Description

Antiplatelet therapy can effectively reduce the occurrence of thrombotic events, which is the primary treatment of cardiovascular and cerebrovascular diseases. However, long-term use of antiplatelet drugs can significantly increase the risk of gastrointestinal mucosal injury, and in severe cases can cause ulcers and bleeding. In patients with gastrointestinal bleeding related to antiplatelet drugs, it is crucial to identify the cause of bleeding, provide effective treatment and adjust antiplatelet treatment in time.

Hematemesis and melena are common clinical manifestations of upper gastrointestinal bleeding, as well as some patients with lower gastrointestinal bleeding.Previous studies have demonstrated that in patients taking long-term antiplatelet drugs, bleeding events occurred not only in the upper digestive tract but also in the lower digestive tract. For patients with hematemesis and melena, clinical guidelines recommend esophagogastroduodenoscopy (EGD) within 24 hours. When EGD fails to find bleeding lesions, clinical guidelines recommend further selection of colonoscopy, capsule endoscopy, enteroscopy, angiography and other methods to find bleeding lesions. However, EGD is invasive and there is potential for procedure-related complications. Besides, EGD can not further evaluate the small bowel, and small bowel mucosal lesions may be missed.

Ds-MCE has offered an noninvasive and safty modality for comprehensive examination of the upper digestive tract and small bowel.ds-MCE adds a detachable string to the conventional MCE, which can control the movement of the capsule through the string in the esophagus. In the process of stomach examination, the capsule position and direction is controlled under the external magnetic field. In the duodenum, ds-MCE can realize repeated observation of duodenum through the joint control of string and magnetic field. At the same time, the battery power of the capsule is longer than 8 hours, and the string can be separated from the capsule after the upper digestive tract examination. For patients with gastrointestinal bleeding undergoing antithrombotic therapy, ds-MCE is comfortable and non-invasive, and can complete upper gastrointestinal and small bowel examinations at one time, which is expected to improve the detection efficiency of bleeding lesions.

This study is a multicenter, prospective study. Patients with antiplatelet drugs-related acute non-hematochezia gastrointestinal bleeding were enrolled. Ds-MCE and EGD were performed successively. This study is aimed to evaluate the diagnostic efficacy of ds-MCE in the detection of bleeding lesions in patients with acute non-hematochezia gastrointestinal bleeding associated with antiplatelet drugs, using EGD as the reference standard.

• Gastrointestinal Bleeding
• Antiplatelet Therapy

• ds-MCE and EGD examinations

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

1. No gender limit, age ≥ 18 years；
2. Acute non-hematochezia gastrointestinal bleeding symptoms, including haematemesis or melena；
3. Taking antiplatelet drugs continuously for at least 14 days；
4. Hemodynamically stable；
5. Able to provide informed consent.

Exclusion Criteria:

1. Age < 18 years；
2. Hemodynamically unstable even after initial volume resuscitation and/or have ongoing fresh hematemesis at presentation；
3. With upper gastrointestinal bleeding caused by peptic ulcer or acute gastric mucosal lesion within 1 month before inclusion；
4. History of endoscopic therapy (such as ESD, EMR, etc.) within 1 month before inclusion；
5. Gastrointestinal tumor, decompensation of cirrhosis with esophageal or gastric varices；
6. Haematopathy and bleeding tendency；
7. Patients who have no surgical conditions or refuse to undergo any abdominal surgery (once the capsule is stuck, it cannot be removed surgically)；
8. Pacemaker or other implanted electromedical devices which could interfere with magnetic resonance；
9. Patients plan to undergo magnetic resonance imaging examination before excretion of the capsule；
10. Suspected or known intestinal stenosis or other known risk factors for capsule retention.
11. Pregnancy；
12. Dysphagia；
13. With and conditon contraindicated to ds-MCE or EGD；
14. With and conditon that is not suitable for participation in the study evaluated by researchers.

Primary Purpose

Diagnostic

Allocation

N/A

Interventional Model

Single Group Assignment

Masking

None (Open Label)

Lead Sponsor

Changhai HospitalOTHER

Collaborators

First Affiliated Hospital Xi'an Jiaotong UniversityOTHER

Qilu Hospital of Shandong UniversityOTHER

zhuanleo@126.com+8613061921980