Prophylactic Amnioinfusion for Prevention of Postpartum Hemorrhage

Prophylactic Amnioinfusion for Prevention of Postpartum Hemorrhage: A Randomized Clinical Trial (PURPOSE)

The purpose of this study is to decrease the likelihood of composite postpartum hemorrhage (PPH) morbidity, which consists of i) Estimated or quantified blood loss of 1,500 mL or more, ii) transfusion of any blood products or iii) hysterectomy

Inclusion Criteria:

• Singletons with a gestational age of 34.0 weeks or more
• Labor (spontaneous or medical induction)
• Medium- or High-risk for PPH, as described by American College of Obstetricians and Gynecologists (ACOG)

Exclusion Criteria:

• Scheduled cesarean delivery
• Multiple gestations
• Delivery at < 34.0 weeks
• Contraindication to place intrauterine pressure catheter (e.g. HIV)
• Incarcerated subjects
• Major fetal anomalies requiring neonatal surgical intervention
• Stillbirth on admission