Oxycodone Versus Sufentanil in Patient-controlled Intravenous Analgesia After Laparoscopic Hysterectomy

The Efficacy and Safety of Oxycodone in Patient-controlled Intravenous Analgesia After Laparoscopic Hysterectomy

This study is designed to evaluate the efficacy and safety of hydrocodone in patient-controlled intravenous analgesia (PCIA) during gynecological laparoscopy, thus to explore suitable PCIA scheme to optimize postoperative pain management for patients undergoing gynecological laparoscopic surgeries.

The controlled group will receive sulfentanil for PCIA, and the test group will receive hydrocodone for PCIA. NRS scores at 1, 6, 24 and 48 hours post-surgery will be recorded. The usage of rescue analgesics and adverse events will also be recorded.

Inclusion Criteria:

• selective laparoscopic hysterectomy
• general anesthesia
• ASA classification I - III
• aged 18 - 65 years

Exclusion Criteria:

• allergy to oxycodone or any other drugs will be used in the study
• preoperative opioids medication
• opioids abuse
• hepatic or renal dysfunction
• cardiovascular or pulmonary dysfunction
• lack of full civil capacity or refuse to participate