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Nootropics are a group of medicinal substances purported to improve important cognitive functions such as learning, focus and memory. Many of these substances have demonstrated beneficial effects on cognitive performance and overall health. However, a thorough understanding of how these substances and their synergistic effects in the form of a supplement may benefit fundamental brain processes is currently lacking. In the current study, we will investigate the effects of a plant-based, nootropic supplement (https://uk.mindlabpro.com/) on perceptual decision-making (i.e. the ability to make rapid decisions based on sensory stimuli) in healthy adult participants.
Participants will perform a computerised cognitive task assessing their perceptual decision-making pre- and post- 60 days of continuous supplementation with either a plant-based nootropic supplement (Mind Lab pro) or placebo. During testing, electroencephalography (EEG) signals will be captured simultaneously.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental group | Experimental | This group will receive the nootropic supplement for 60 days. |
|
| Control group | Placebo Comparator | This group will receive a placebo supplement for 60 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nootropics (ginkgo biloba, nicergoline, piracetam, or others) | Dietary Supplement | Commercially available product: Mind lab pro |
|
| Measure | Description | Time Frame |
|---|---|---|
| Perceptual decision-making performance | Choice accuracy and reaction times | Pre- and post- 60 days of supplementation |
| Measure | Description | Time Frame |
|---|---|---|
| Brain network interdependencies | Patterns extracted from brain signals using electroencephalography | Pre- and post- 60 days of supplementation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ioannis Delis | University of Leeds | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Biological sciences | Leeds | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40149748 | Derived | O'Reilly D, Bolam J, Delis I, Utley A. Effect of a Plant-Based Nootropic Supplement on Perceptual Decision-Making and Brain Network Interdependencies: A Randomised, Double-Blinded, and Placebo-Controlled Study. Brain Sci. 2025 Feb 21;15(3):226. doi: 10.3390/brainsci15030226. |
| Label | URL |
|---|---|
| Pre-registration of the study | View source |
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No further investigations will take place using this data with anyone outside of the current research group
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| ID | Term |
|---|---|
| D018697 | Nootropic Agents |
| D000096983 | Ginkgo Extract |
| D009530 | Nicergoline |
| D010889 | Piracetam |
| D004569 | Electroencephalography |
| ID | Term |
|---|---|
| D002491 | Central Nervous System Agents |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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| Placebo | Dietary Supplement | A cellulose commonly used as a bulking agent in supplement products |
|
| Perceptual decision-making performance | Behavioral | A computerised cognitive task involving rapid visual categorisation of images |
|
| Electroencephalography | Device | Brain signals are recorded from a 64 channel EEG system during the cognitive task |
|
| D010936 | Plant Extracts |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D004873 | Ergolines |
| D004876 | Ergot Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D000081 | Acetamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000085 | Acetates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D011760 | Pyrrolidinones |
| D011759 | Pyrrolidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D003943 | Diagnostic Techniques, Neurological |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D004568 | Electrodiagnosis |