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This study collected general data from 90 patients with KOA in the outpatients and ward of Henan Provincial People's Hospital from January 2023 to December 2023 to compare the long-term effects of intra-articular PRP combined with acupoint PRP, intra-articular PRP, and intra-articular HA on symptoms in patients with mild to moderate osteoarthritis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HA group | No Intervention | treated with intra-articular injection of hyaluronic acid solution, 2 ml per injection, and 1 ml of normal saline injection at Xuehai, Yanglingquan, and Weizhong acupoints at the same time, once a week for 4 weeks | |
| PRP joint injection group | Placebo Comparator | treated with intra-articular injection of PRP, 3.5 ml per injection, and 1 ml of normal saline injection at Xuehai, Yanglingquan, and Weizhong acupoints at the same time, once a week for 4 weeks |
|
| PRP joint injection combined with acupoint injection group | Experimental | treated with intra-articular injection of PRP, 3.5 ml per injection, and 1 ml of PRP injection at Xuehai, Yanglingquan, and Weizhong acupoints at the same time, once a week for 4 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PRP joint injection combined with acupoint injection | Other | PRP acupoint injection |
|
| Measure | Description | Time Frame |
|---|---|---|
| Visual Analog Scale (VAS) score | Visual Analog Scale (VAS) score ranging from 1 to 10, with lower scores indicating less pain intensity | Assessments will be conducted at weeks 1, 3, 6, and 12 after treatment. |
| Knee Society Score (KSS) | Knee Society Score (KSS), which consists of five major items totaling 200 points. Higher scores indicate better knee joint function | Assessments will be conducted at weeks 1, 3, 6, and 12 after treatment. |
| Western Ontario and McMaster Universities Osteoarthritis Index | The severity of knee osteoarthritis was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, consisting of 24 items with a total possible score of 240 points. Lower WOMAC scores indicate less severe knee osteoarthritis. | Assessments will be conducted at 1, 3, 6, and 12 months after treatment. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| No.7, Wei Wu Road, Zhengzhou City | Zhengzhou | Henan | 450000 | China |
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| ID | Term |
|---|---|
| D015669 | Acupuncture Points |
| ID | Term |
|---|---|
| D016740 | Meridians |
| D015670 | Acupuncture Therapy |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
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90 subjects were randomly divided into three groups, with 30 cases in each group. (1) HA group: The patients were given intraarticular injection of sodium hyaluronate injection, 2ml each time, and normal saline injection of 1ml at Xuehai point, Yanglingquan point and Wezhong point, once a week for 4 weeks. (2) PRP joint cavity injection group: PRP knee cavity injection was given, 3.5ml each time, and normal saline injection was given at Xuechai point, Yanglingquan point and Weizhong point 1ml, once a week for 4 weeks; (3) PRP joint cavity combined with acupoint injection group: PRP was given intraventricular injection of knee joint, each injection was 3.5ml, while PRP was given 1ml injection of Xuehai point, Yanglingquan point and Weizhong point, once a week for 4 weeks.
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