Heart failure with preserved ejection fraction (HFpEF) has grown to become the dominant form of heart failure (HF) worldwide, in tandem with ageing of the general population and the increasing prevalence of obesity, diabetes mellitus and hypertension. In 2020, > 70% of patients with heart failure had preserved ejection fraction. The incidence and prevalence of HFpEF has been growing by 10% every 10 years relative to HF with reduced ejection fraction (HFrEF). In 2017, the prevalence of HFpEF varied from 1% to 14% based on available data from Europe and USA. HFpEF is associated with high morbidity and mortality, and patients with HFpEF have similarly high hospitalization rates as patients with HFrEF. Hence, HFpEF poses a substantial global health challenge. Despite its prevalence, HFpEF remains undiagnosed and underrecognized, necessitating a comprehensive approach to both identification and management.

Ensuring successful treatment necessitates early identification of HFpEF. Consequently, a targeted screening strategy has been devised for the identification of HFpEF patients. Given the higher prevalence of heart failure (HF) in the elderly population, testing the screening strategy is imperative to customize it to the specific needs of vulnerable patients who may be more inclined to decline participation in the screening program.

The study is a prospective, observational cohort study. Using risk factors for HFpEF, the Danish National Health Registries will be used to identify up to 5000 citizens with at least one risk factor for HFpEF relying on International Classification of Diseases, 10th revision (ICD-10), medication, and biochemistry. The investigators will only recruit patients from the Capital Region of Denmark. Participants will be recruited by sending recruitment letters to a secure electronic mailbox (eBoks) linked to the patients' social security numbers.

The purpose of this study is to evaluate the identification and screening procedures for HFpEF outlined in this protocol. Additionally, the investigators aim to gauge the willingness of identified Danish adults with risk factors for HFpEF to participate in the study and to identify and address any barriers to their involvement. Overall, the investigators expect the results of this study can be used to guide future initiatives aimed at improving the identification and enrollment of patients with HFpEF, particularly among vulnerable populations.

Inclusion Criteria:

1. Residence in the Capital Region of Denmark

2. Age ≥ 50 years

3. At least two risk factors for HFpEF defined as any of the following (for age ≥ 60 years, only one):

   • Hypertension
   • Diabetes mellitus
   • Chronic kidney disease
   • Atrial fibrillation
   • BMI > 25 kg/m2
   • Previous heart valve surgery
   • Ischemic heart disease
   • Obstructive sleep apnea
   • Furosemide 40 mg

Exclusion Criteria:

1. Age ≥ 90 years

2. Prevalent HF

3. Dementia

4. Nursing home

5. Amyloidosis

6. Hemodialysis

7. Cancer diagnosed within the past 5 years (skin cancer not included)

8. Prior solid organ transplantation

9. Lung disease defined as any of the following:

   • World Health Organization Group 1 pulmonary hypertension
   • Chronic pulmonary embolism
   • Lung fibrosis
   • Chronic obstructive pulmonary disease (COPD)
   • Home oxygen

5000 citizens aged 50 years or above in the Capital Region of Denmark with at least two risk factors for HFpEF (for age ≥ 60 years, only one).

Most data will be collected from Danish administrative health registries, which are subject to Danish legislation and can only be made available to a third party under certain conditions. Please contact the sponsor-investigator in case of any inquiries.