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This is an observational , multicenter, real-world study aimed at evaluating the efficacy and safety of the combination of immune checkpoint inhibitors, chidamide and antiangiogenic agents in Microsatellite Stable advanced colorectal cancer patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| chidamide + PD-1/PD-L1 inhibitors +Bevacizumab or tyrosine kinase inhibitors |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Chidamide, Tucidinostat; PD-1/PD-L1 inhibitor or double antibodies; Bevacizumab or tyrosine kinase inhibitors | Drug | Chidamide, Tucidinostat; PD-1/PD-L1 inhibitor or double antibodies; Bevacizumab or tyrosine kinase inhibitors |
| Measure | Description | Time Frame |
|---|---|---|
| Progression-free survival(PFS) | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Objective Response Rate（ORR） | 2 years | |
| Clinical Benefit Rate (CBR) | 2 years | |
| Disease Control Rate （DCR） |
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Inclusion Criteria:
Exclusion Criteria:
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advanced/metastatic MSS colorectal cancer patients
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| feng wang | Contact | 020-87343088 | wangfeng@sysucc.org.cn |
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| 2 years |
| Overall survival (OS) | 2 years |
| ID | Term |
|---|---|
| C547816 | N-(2-amino-5-fluorobenzyl)-4-(N-(pyridine-3-acrylyl)aminomethyl)benzamide |
| D000068258 | Bevacizumab |
| D000092004 | Tyrosine Kinase Inhibitors |
| ID | Term |
|---|---|
| D061067 | Antibodies, Monoclonal, Humanized |
| D000911 | Antibodies, Monoclonal |
| D000906 | Antibodies |
| D007136 | Immunoglobulins |
| D007162 | Immunoproteins |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D012712 | Serum Globulins |
| D005916 | Globulins |
| D047428 | Protein Kinase Inhibitors |
| D004791 | Enzyme Inhibitors |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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