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Over 300 million surgeries are performed globally every year. Complications after surgery - infections, cardiovascular conditions, postoperative pulmonary complications and renal impairment - affect survival and quality of life.
Age and co-morbidity are unmodifiable factors, contributing to increased risk of these perioperative complications. However, a modifiable risk factor is physical activity. This study aims to test if self reported physical activity is associated to lower risk of perioperative morbidity and mortality.
Research question: This cohort study investigates if higher levels of self reported physical activity at preoperative assessment is associated to lower risk of complications and lower mortality.
Background: Previous studies of perioperative outcomes in high-income countries indicate that close to 20% had complications within 30 days after surgery, and that around 3% died within 1 yr after surgery. In multiple studies, postoperative complications massively increase risk of 1yr mortality. Whilst perioperative complications are under-reported, they affect length of stay and days at home up to 30 days after surgery (DAH30). DAH30 is a validated, patient-centered outcome measure with prognostic importance due to high sensitivity to changes in surgical risks and the impact of surgical complications.
Data collection: Age, sex, body mass index, co-morbid conditions (using ICD-codes and reported medication) as well as American Society of Anesthesiologists (ASA) physical status classification will be recorded. Exposure: the Metabolic Equivalent of Task Score (MET-score), reported in the electronic health record by the attending anesthesiologist based on patient history in conjunction with the preoperative assessment.
Analysis: The MET-score is the exposure/the dependent variable and the other factors will be used in multivariable analyses.
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| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Death within the time frames described below | Mortality will be recorded at 30, 60, 90 and 365 days after index surgery |
| DAH30 (Days At Home alive at 30 days) | DAH30: Patients who are hospitalized for 14 days postoperatively but are alive on day 30 will have DAH30=16. Patients who are hospitalized for five days, then discharged, but return after 10 days for an additional 11-day stay, will have DAH30=14. Anyone who dies within 30 days will have DAH30=0. This outcome measure is validated in several studies and has a significant advantage in that it correlates well with complications, even better than length of stay (LOS). We will further record DAH90 and DAH365, calculated as described above. | 30, 90 and 365 days after index surgery, |
| Measure | Description | Time Frame |
|---|---|---|
| Length of stay | Number of days in the hospital after index surgery | One year after index surgery |
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Inclusion Criteria:
Adult patients (equal to or over 18 years) undergoing elective non-cardiac surgery at the two study sites, Karolinska University Hospital Solna and Karolinska University Hospital Huddinge
Exclusion Criteria:
Patients under the age of 18, transplant, day surgery, acute surgery, anesthesia monitoring, brachy therapy and gamma knife interventions. In case of multiple surgeries, only the first will be included.
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Adult patients (equal to or over 18 years) undergoing elective non-cardiac surgery
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Max Bell, MD, PhD | Contact | +46708278533 | max.bell@regionstockholm.se | |
| Arman Valadkhani, MD | Contact | arman.valadkhani@regionstockholm.se |
| Name | Affiliation | Role |
|---|---|---|
| Max Bell, MD, PhD | Karolinska Institutet | Principal Investigator |
| Arman Valadkhani, MD | Karolinska Institutet | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Karolinska Institutet | Recruiting | Stockholm | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41043174 | Derived | Valadkhani A, Sebghati S, Piehl J, Bell M. Impact of Preoperative Functional Capacity on Postoperative Mortality and Morbidity: A Prospective Cohort Study. Anesthesiology. 2026 Mar 1;144(3):525-534. doi: 10.1097/ALN.0000000000005779. Epub 2025 Oct 3. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Mar 26, 2025 | Jun 2, 2025 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D057185 | Sedentary Behavior |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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