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| Name | Class |
|---|---|
| Military University Hospital, Prague | OTHER |
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This study investigates the development of intra-abdominal hypertension and compartment syndrome in patients undergoing elective pancreatic procedures. Main objective is to determine the proportion of patients after pancreatic operation who develop elevated intra-abdominal pressure and assess its association with postoperative complication rates. Another goal of the study is to compare open versus robotic pancreatic procedures regarding the occurrence of intra-abdominal hypertension and abdominal compartment syndrome.
HYPA study is designed as a prospective observational study. The primary objective of this study is to assess the risk and prevalence of intra-abdominal hypertension and abdominal compartment syndrome following pancreatic procedures. The secondary objective aims to explore potential correlations between intra-abdominal hypertension and the development of postoperative complications, such as anastomotic dehiscence, postoperative pancreatic fistulas, prolonged postoperative ileus, or delayed gastric emptying. The third objective is to compare the incidence of intra-abdominal hypertension in patients undergoing robotic versus open pancreatic procedures
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients after pancreatic procedures | All patients following pancreatic procedure |
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| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of Intra-abdominal hypertension and abdominal compartment syndrome | Prevalence of intra-abdominal hypertension and abdominal compartment syndrome in patients following pancreatic procedures. | From the admission to the intensive care unit until the postoperative day 7 or until discharge from the ICU |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between intra-abdominal hypertension and the development of postoperative complications. | The secondary objective aims to explore potential correlations between intra-abdominal hypertension and the development of postoperative complications, such as anastomotic dehiscence, postoperative pancreatic fistulas, prolonged postoperative ileus, or delayed gastric emptying. | From the enrollment to the 90 days follow up period. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Intra-abdominal hypertension in patients following robotic vs. open pancreatic procedure. | The tertiary objective is to compare open and robotic pancreatic procedures in terms of incidence of intra-abdominal hypertension and ACS | From the admission to the intensive care unit for 7 consecutive days or until discharge from the ICU. |
Inclusion Criteria:
Exclusion Criteria:
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All patients undergoing open or robotic pancreatic procedures in our department.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Štěpán-Ota Schütz, MD. | Contact | 00420 733224640 | stepan.sch@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Pavel Záruba, MD. | Department of Surgery 2nd Faculty of Medicine, Charles University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Surgery 2nd Faculty of Medicine, Charles University and Military University Hospital Prague | Prague | Prague 6 | 169 02 | Czechia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33001288 | Background | Smit M, Koopman B, Dieperink W, Hulscher JBF, Hofker HS, van Meurs M, Zijlstra JG. Intra-abdominal hypertension and abdominal compartment syndrome in patients admitted to the ICU. Ann Intensive Care. 2020 Oct 1;10(1):130. doi: 10.1186/s13613-020-00746-9. | |
| 30608280 | Background | Reintam Blaser A, Regli A, De Keulenaer B, Kimball EJ, Starkopf L, Davis WA, Greiffenstein P, Starkopf J; Incidence, Risk Factors, and Outcomes of Intra-Abdominal (IROI) Study Investigators. Incidence, Risk Factors, and Outcomes of Intra-Abdominal Hypertension in Critically Ill Patients-A Prospective Multicenter Study (IROI Study). Crit Care Med. 2019 Apr;47(4):535-542. doi: 10.1097/CCM.0000000000003623. |
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All collected IPD that underlie results in a publication
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| 35744049 | Background | Mancilla Asencio C, Berger Fleiszig Z. Intra-Abdominal Hypertension: A Systemic Complication of Severe Acute Pancreatitis. Medicina (Kaunas). 2022 Jun 10;58(6):785. doi: 10.3390/medicina58060785. |
| 15310355 | Background | Hunter JD, Damani Z. Intra-abdominal hypertension and the abdominal compartment syndrome. Anaesthesia. 2004 Sep;59(9):899-907. doi: 10.1111/j.1365-2044.2004.03712.x. |
| 18841232 | Background | Ball CG, Kirkpatrick AW, McBeth P. The secondary abdominal compartment syndrome: not just another post-traumatic complication. Can J Surg. 2008 Oct;51(5):399-405. |
| 33968300 | Background | Leon M, Chavez L, Surani S. Abdominal compartment syndrome among surgical patients. World J Gastrointest Surg. 2021 Apr 27;13(4):330-339. doi: 10.4240/wjgs.v13.i4.330. |
| 10522851 | Background | Sugrue M, Jones F, Deane SA, Bishop G, Bauman A, Hillman K. Intra-abdominal hypertension is an independent cause of postoperative renal impairment. Arch Surg. 1999 Oct;134(10):1082-5. doi: 10.1001/archsurg.134.10.1082. |
| 7749700 | Background | Sugrue M, Buist MD, Hourihan F, Deane S, Bauman A, Hillman K. Prospective study of intra-abdominal hypertension and renal function after laparotomy. Br J Surg. 1995 Feb;82(2):235-8. doi: 10.1002/bjs.1800820234. |
| 29937073 | Background | Gray S, Christensen M, Craft J. The gastro-renal effects of intra-abdominal hypertension: Implications for critical care nurses. Intensive Crit Care Nurs. 2018 Oct;48:69-74. doi: 10.1016/j.iccn.2018.06.001. Epub 2018 Jun 21. |
| 21184922 | Background | De Waele JJ, De Laet I, Kirkpatrick AW, Hoste E. Intra-abdominal Hypertension and Abdominal Compartment Syndrome. Am J Kidney Dis. 2011 Jan;57(1):159-69. doi: 10.1053/j.ajkd.2010.08.034. |
| 23673399 | Result | Kirkpatrick AW, Roberts DJ, De Waele J, Jaeschke R, Malbrain ML, De Keulenaer B, Duchesne J, Bjorck M, Leppaniemi A, Ejike JC, Sugrue M, Cheatham M, Ivatury R, Ball CG, Reintam Blaser A, Regli A, Balogh ZJ, D'Amours S, Debergh D, Kaplan M, Kimball E, Olvera C; Pediatric Guidelines Sub-Committee for the World Society of the Abdominal Compartment Syndrome. Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome. Intensive Care Med. 2013 Jul;39(7):1190-206. doi: 10.1007/s00134-013-2906-z. Epub 2013 May 15. |
| 41219702 | Derived | Schutz SO, Zaruba P, Rara A, Sotak M, Havlikova S, Modrak M, Tyll T, Pohnan R. HYPA study: protocol for investigating intra-abdominal hypertension and abdominal compartment syndrome in patients undergoing open and robotic pancreatic procedures. BMC Surg. 2025 Nov 11;25(1):536. doi: 10.1186/s12893-025-03294-w. |
| ID | Term |
|---|---|
| D059325 | Intra-Abdominal Hypertension |
| D018589 | Gastroparesis |
| D057868 | Anastomotic Leak |
| D004487 | Edema |
| D003161 | Compartment Syndromes |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D013272 | Stomach Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D010243 | Paralysis |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
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