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Choice of local anesthetics is the major determinant of the characteristics of a peripheral nerve block. Short acting local anesthetics while provides faster onset suffer from shorter duration. On the other hand, long acting local anesthetics while provides long duration suffered from long onset time. The ideal local anesthetics should provide faster nerve block onset while providing reasonable duration to provide sustained postoperative analgesia. Mixing short and long acting local anesthetics for nerve blocks may appear to be the solution however previous published studies have demonstrated similar onset time to long acting local anesthetics and with reduced duration. Recently, the London Health Sciences Centre established an ambulatory surgical centre. Fast onset peripheral nerve block is desirable. Previous studies have not looked at popliteal sciatic block and anecdotally we feel addition of short acting local anesthetics appear to speed up onset. We are therefore interested in conducting a randomize trial to determine whether mixing short and long acting local anesthetics can speed up onset of surgical quality block.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ropivacaine | Active Comparator | Popliteal block using Ropivacaine 100 mg in 20 mL |
|
| Ropivacaine anmd Lidocaine | Experimental | Popliteal sciatic block using Ropivacaine 100 mg and Lidocaine 100 mg in 20 mL |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ropivacaine and Lidocaine | Drug | Popliteal sciatic block using Ropivacaine 100 mg and Lidocaine 100 mg in 20 mL |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to complete sensory block | The primary outcome is onset time for achievement of complete sensory block of the sciatic nerve determined via pinch test. | Tested every 2 min up to 60 min |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of analgesia | Patient self reported time to onset of pain or analgesics | up to 48 hours after discharge |
| Pain score at 6 hour post-block | Numeric rating scale of patient self-reported pain at 6 hour after block placement |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Cheng Lin | Contact | 5196858500 | cheng.lin@lhsc.on.ca |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17356507 | Result | Bugamelli S, Zangheri E, Montebugnoli M, Borghi B, Ricci A, De Simone N, Bonfatti M, Elmar K, Luppi M, Pignotti E. One-day surgery for acquired forefoot deformity: sciatic nerve blockade with mepivacaine vs mepivacaine+ropivacaine: a prospective, randomized study. Minerva Anestesiol. 2007 Jan-Feb;73(1-2):57-64. | |
| 19151302 | Result |
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This will require REb approval
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| ID | Term |
|---|---|
| D000077212 | Ropivacaine |
| D008012 | Lidocaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| Ropivacaine 0,5% | Drug | Popliteal sciatic block using ropivacaine 0.5% 20 mL |
|
| 6 hours after nerve block |
| Patient satisfaction | 5 point categorical | at 48 hour |
| Cuvillon P, Nouvellon E, Ripart J, Boyer JC, Dehour L, Mahamat A, L'hermite J, Boisson C, Vialles N, Lefrant JY, de La Coussaye JE. A comparison of the pharmacodynamics and pharmacokinetics of bupivacaine, ropivacaine (with epinephrine) and their equal volume mixtures with lidocaine used for femoral and sciatic nerve blocks: a double-blind randomized study. Anesth Analg. 2009 Feb;108(2):641-9. doi: 10.1213/ane.0b013e31819237f8. |
| 23904938 | Result | Valery P, Aliaksei M. A comparison of the onset time of complete blockade of the sciatic nerve in the application of ropivacaine and its equal volumes mixture with lidocaine: a double-blind randomized study. Korean J Anesthesiol. 2013 Jul;65(1):42-7. doi: 10.4097/kjae.2013.65.1.42. Epub 2013 Jul 19. |
| 22985391 | Result | Chen L, Wang Q, Shi K, Liu F, Liu L, Ni J, Fang X, Xu X. The effects of lidocaine used in sciatic nerve on the pharmacodynamics and pharmacokinetics of ropivacaine in sciatic nerve combined with lumbar plexus blockade: a double-blind, randomized study. Basic Clin Pharmacol Toxicol. 2013 Mar;112(3):203-8. doi: 10.1111/bcpt.12008. Epub 2012 Dec 6. |
| D000588 |
| Amines |
| D000083 | Acetanilides |