iTBS in MCI and Mild AD

The Effects of Intermittent Theta-burst Stimulation on Cognitive Function in Patients With Mild Cognitive Impairment and Mild Alzheimer's Disease and the Role of Brain-Derived Neurotrophic Factor

This study aims to examine the effects of iTBS on cognitive function in individuals with MCI or mild AD, with a secondary objective of exploring prefrontal TBS mechanisms for cognitive function and the effect of iTBS on BDNF.

Inclusion Criteria:

• Clinical diagnosis of MCI (overall Clinical Dementia Rating of 0.5)
• Clinical diagnosis of mild Alzheimer's Disease (overall Clinical Dementia Rating of 0.5 or 1)

Exclusion Criteria:

• History of stroke
• History of uncontrol seizure
• History of significant head trauma followed by persistent neurologic deficit or known structural brain abnormality
• Mental illness
• Drug abuse