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The aim of this work is to compare atenolol, propranolol, and ivabradine as a premedication to achieve bloodless field anesthesia primarily controlling heart rate in lumbar spine surgery.
This study will investigate the effect of atenolol, propranolol, and ivabradine as oral premedication in adult patients undergoing LUMBAR SPINE SURGERY to achieve bloodless field anesthesia.
AIM OF THE WORK
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Atenolol Group | Active Comparator | patients will be premedicated with atenolol (50mg) |
|
| propranolol Group | Active Comparator | patients will be premedicated with propranolol (10mg) |
|
| Ivabradine Group | Active Comparator | patients will be premedicated with Ivabradine (5mg) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Atenolol 50 MG | Drug | patients will be premedicated with atenolol (50mg) |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Perioperative Heamodynamic Effect of the drugs | Heart rate | every 5 minutes for 15 minutes and then every 10 minutes till end of surgery, then every 15 minutes for 1hour in the recovery room |
| Measure | Description | Time Frame |
|---|---|---|
| Blood loss & surgical field visibility score | quality scale proposed by Fromm and Boezaart | Intraoperative time |
| Anesthetic consumption | Propofol, opioid, and isoflurane consumption |
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Inclusion Criteria:
ASA physical status I and II,
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Menoufia University | Shepien El Kom | Menoufia Government | 32817 | Egypt |
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| ID | Term |
|---|---|
| D016063 | Blood Loss, Surgical |
| ID | Term |
|---|---|
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007431 | Intraoperative Complications |
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| ID | Term |
|---|---|
| D001262 | Atenolol |
| D011433 | Propranolol |
| D000077550 | Ivabradine |
| ID | Term |
|---|---|
| D050198 | Phenoxypropanolamines |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
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| Propranolol Pill |
| Drug |
patients will be premedicated with propranolol (10mg) |
|
| Ivabradine | Drug | patients will be premedicated with Ivabradine (5mg) |
|
| Intraoperative time |
| Incidence of complication | The patient will be examined for bradycardia, or tachycardia hypo or hypertension, shivering, respiratory depression, dizziness, visual disturbance, nausea, and vomiting | Intraoperative time |
| The need for blood transfusion | The need for blood transfusion | Intraoperative time |
| D009930 |
| Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |
| D009281 | Naphthalenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D001552 | Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |