Effectiveness of Early Intervention in Transfusion Independent Aplastic Anemia: a Retrospective Medical Claims Database Study

Effectiveness of Early Intervention in Transfusion Independent Aplastic Anemia: a Retrospective Medical Claims Database Study

This was a retrospective non-interventional cohort study with secondary use of data from the Medical Data Vision (MDV) hospital-based database to evaluate the effectiveness of early drug intervention in preventing transfusion compared to watchful observation among adult transfusion-independent aplastic anemia (AA) patients in Japan.

Inclusion Criteria:

• Having at least one confirmed diagnosis of AA within the selection period (1 inpatient or 2 outpatient claims per the International Statistical Classification of Diseases, 10th Revision [ICD-10] code, without any suspicion flag).
• Being aged 15 to 90 years at the index date.
• Having at least 3 months of continuous enrolment prior to the index date.

Exclusion Criteria:

• Having a blood transfusion recorded any time before the index date.
• Having anti-thymocyte globulin (ATG) treatment recorded within 3 months after the index date.
• Having at least one prescription record for any of the drug treatments of interest any time before the index date.
• Having a diagnosis of acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML) or other leukemia any time before the index date.
• Having an AA diagnosis (without suspicious flag) date earlier than the start of patient's observation in the database.
• Having less than 6 months of continuous follow-up.

Safety Population - Additional Exclusion Criterion:

- Having a diagnosis of hepatotoxicity, kidney dysfunction, hypertension, or diabetes mellitus any time before the index date.