The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic

Therapeutic Efficacy of Local Vitamin D Drug as an Adjunct to Mechanical Debridement in the Treatment of Periodontitis

The proposed study aims to investigate the impact of adjunctive vitamin D gel application on gingival crevicular fluid levels of alkaline phosphatase and interleukin-8 in periodontitis patients undergoing phase 1 periodontal therapy. By elucidating the molecular mechanisms underlying the therapeutic effects of vitamin D, this research seeks to contribute to the development of more effective treatment strategies for periodontitis.

Inclusion Criteria:

• Patients with attachment loss 3-4 mm
• periodontal pocket ≤ 5 mm

Exclusion Criteria:

• - Patients with sensitivity to the medication used in the study.
• Patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study.
• Patients with systemic diseases.
• Pregnant and lactating females.
• Smokers and tobacco chewers.
• Patients not compliant with oral hygiene procedures.