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For participation in this epidemiological study, a single-day visit at the study site is required. Participants will be recruited from Huntington Disease clinics, and they will be asked to answer questions regarding their demographics, including sex, age, race and ethnicity, and their medical and medication history. At the end of the visit, a blood sample will be drawn to allow testing with a sequencing assay that is specifically designed for phasing single nucleotide polymorphisms (SNPs) on the wild-type Huntington (wtHTT) and mutant Huntington (mHTT) alleles.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants Who Are Huntington Disease Gene Expansion Carriers |
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| Measure | Description | Time Frame |
|---|---|---|
| Frequencies of Selected Single Nucleotide Polymorphism (SNP) Alleles in Phase With the mHTT and wtHTT Alleles | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants With Selected SNPs According to Their Medical History | Day 1 | |
| Number of Participants With Selected SNPs According to Their Medication History | Day 1 | |
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Inclusion Criteria:
Exclusion Criteria:
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This epidemiological study will be conducted in ambulatory men and women aged 25 to 60 years old (inclusive) who carry the Huntington Disease (HD) gene expansion and meet the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score (TMS) and Total Functional Capacity (TFC) criteria for HD Integrated Staging System (HD-ISS) Stages 2-3.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Reference Study ID Number: WE45491 https://forpatients.roche.com/ No attachments to email below. | Contact | 888-662-6728 (U.S. Only) | global-roche-genentech-trials@gene.com | |
| Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry | Contact |
| Name | Affiliation | Role |
|---|---|---|
| Clinical Trials | Hoffmann-La Roche | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uab Medicine | Completed | Birmingham | Alabama | 35294 | United States | |
| Barrow Neurological Institute |
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| Label | URL |
|---|---|
| Please use this form to submit your questions for a faster response: https://www.gene.com/contact-us/submit-medical-inquiry. Do not include or attach any medical records when emailing or completing the form. A nurse will respond within 24 business hours. | View source |
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Blood sample
| Number of Participants With Selected SNPs According to Their Demographic Characteristics (Age, Sex, Ethnicity, and Race) |
| Day 1 |
| Completed |
| Phoenix |
| Arizona |
| 85013 |
| United States |
| University of California San Diego | Completed | La Jolla | California | 92037-1337 | United States |
| University of California Davis Medical System | Completed | Sacramento | California | 95817 | United States |
| CenExel Rocky Mountain Clinical Research, LLC | Completed | Englewood | Colorado | 80113 | United States |
| University of South Florida | Completed | Tampa | Florida | 33612 | United States |
| Northwestern University | Completed | Chicago | Illinois | 60611 | United States |
| University of Iowa Hospitals and Clinics | Completed | Iowa City | Iowa | 52242 | United States |
| John Hopkins University School of Medicine | Completed | Baltimore | Maryland | 21287 | United States |
| Beth Israel Deaconess Medical Center | Completed | Boston | Massachusetts | 02215 | United States |
| University of Pittsburgh | Completed | Pittsburgh | Pennsylvania | 15213 | United States |
| Vanderbilt University Medical Center | Recruiting | Nashville | Tennessee | 37212 | United States |
| EvergreenHealth Investigational Drug Services | Completed | Kirkland | Washington | 98034 | United States |
| Hospital Britanico de Buenos Aires | Completed | Ciudad Autonoma Buenos Aires | C1284AEB | Argentina |
| Calvary Health Care Bethlehem | Recruiting | Caulfield South | New South Wales | 3162 | Australia |
| Westmead Hospital | Recruiting | Westmead | New South Wales | 2145 | Australia |
| Royal Melbourne Hospital | Recruiting | Parkville | Victoria | 3050 | Australia |
| Graylands Hospital | Recruiting | Mount Claremont | Western Australia | 6010 | Australia |
| University of Alberta | Recruiting | Edmonton | Alberta | T6G 2G3 | Canada |
| University of British Columbia Hospital | Recruiting | Vancouver | British Columbia | V6T 2B5 | Canada |
| Centricity Research | Recruiting | Halifax | Nova Scotia | B3S 1N2 | Canada |
| North York General Hospital | Recruiting | Toronto | Ontario | M2J 1V1 | Canada |
| McGill University | Recruiting | Montreal | Quebec | H3A 2B4 | Canada |
| Rigshospitalet, Hukommelsesklinikken | Recruiting | København Ø | 2100 | Denmark |
| Charité - Universitätsmed. Berlin, Klinik für Psychiatrie und Psychotherapie | Recruiting | Berlin | 10117 | Germany |
| St. Josef-Hospital, Neurologische Klinik der Ruhr-Uni | Completed | Bochum | 44791 | Germany |
| Universitätsklinikum Erlangen, Abteilung Molekulare Neurologie | Recruiting | Erlangen | 91054 | Germany |
| Universitätsklinikum Ulm | Recruiting | Ulm | 89081 | Germany |
| Fondazione IRCCS Istituto Neurologico Carlo Besta | Recruiting | Milan | Lombardy | 20133 | Italy |
| Universita Degli Studi Di Firenze | Recruiting | Florence | Tuscany | 50134 | Italy |
| Auckland DHB - Neurlogy Department | Recruiting | Auckland | New Zealand |
| New Zealand Brain Research Institute | Completed | Christchurch | 8011 | New Zealand |
| Wellington Hospital | Recruiting | Wellington | 6021 | New Zealand |
| Szpital Sw. Wojciecha | Recruiting | Gda?sk | 80-462 | Poland |
| Wojskowy Instytut Medycyny Lotniczej | Recruiting | Warsaw | 01-755 | Poland |
| Unidade Local de Saude de Santa Maria, E.P.E. - Hospital de Santa Maria | Recruiting | Lisbon | 1649-035 | Portugal |
| CNS - Campus Neurológico | Completed | Torres Vedras | 2560-280 | Portugal |
| Hospital Universitario de Badajoz | Recruiting | Badajoz | 06080 | Spain |
| Hospital de la Santa Creu i Sant Pau | Recruiting | Barcelona | 08041 | Spain |
| Hospital Universitario de Burgos. Servicio de Neurología | Recruiting | Burgos | 09006 | Spain |
| Hospital Ramon y Cajal | Recruiting | Madrid | 28034 | Spain |
| Birmingham and Solihull Mental Health Foundation NHS Trust | Recruiting | Birmingham | B16 8PF | United Kingdom |
| Addenbrookes Hospital | Recruiting | Cambridge | CB2 0QQ | United Kingdom |
| National Hospital For Neurology and Neurosurgery | Recruiting | London | WC1N 3BG | United Kingdom |
| John Radcliffe Hospital | Recruiting | Oxford | OX3 9DU | United Kingdom |
| ID | Term |
|---|---|
| D006816 | Huntington Disease |
| ID | Term |
|---|---|
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D003704 | Dementia |
| D002819 | Chorea |
| D020820 | Dyskinesias |
| D009069 | Movement Disorders |
| D020271 | Heredodegenerative Disorders, Nervous System |
| D019636 | Neurodegenerative Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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