Evaluating Modulation Effects of Burst Stimulation Patterns Using SEEG

Evaluating Modulation Effects of Burst Stimulation Patterns Using SEEG

The study aims to evaluate modulation effects of burst stimulation patterns via SEEG.

Our research group plans to conduct a study on patients with drug-resistant epilepsy who have SEEG electrodes implanted. The study will evaluate and compare the modulation effect of single-pulse electrical stimulation, paired electrical stimulation, stepwise electrical stimulation, and burst electrical stimulation via direct electrical stimulation using SEEG. The goal is to explore the focal and network modulation effect of distinct stimulation paradigms during the resting state and post-seizure state.

Inclusion Criteria:

• Drug-resistant focal epilepsy
• Justified SEEG exploration in the context of presurgical assessment of epilepsy
• Subjects will be a part of the epilepsy-monitoring unit for long-term SEEG recordings and analysis
• Written non-opposition to study participation

Exclusion Criteria:

• Pregnant women (Contraindication to SEEG exploration)
• Psychiatric disorders
• History of psychotic disorders
• History of cranial trauma serious (according to the classification), previous or evolutionary other neurological pathology
• Subjects that experience surgical complications during the implant procedure will be excluded from the study