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| ID | Type | Description | Link |
|---|---|---|---|
| SW-001 | Other Identifier | department of neurosurgery in Tongji hospital |
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The goal of this observational study is to learn about the anti-inflammatory effects of anesthetics on patients undergoing endovascular coiling of cerebral aneurysm. The main question it aims to answer is:
Does sevoflurane or propofol affect the inflammatory response in subarachnoid hemorrhage?
Participants already undergoing endovascular coiling of cerebral aneurysm will have their serum levels of inflammatory factors measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients undergoing endovascular coiling of cerebral aneurysm in Tongji hospital | The present clinical study was carried out with the aim of determine whether the inflammatory effect differs when using propofol or sevoflurane anesthesia. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Anesthesia Agent | Drug | intravenous anesthetic and inhalation anesthetic |
|
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of interleukin-10 | Test the concentration of interleukin-10 of the participants | From enrollment to 3 months postoperation |
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of interleukin-1 | Test the Concentration of interleukin-1 in participants | From enrollment to 3 months postoperation |
| Concentration of interleukin-2 | Test the concentration of interleukin-2 in participants |
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Inclusion Criteria:
Exclusion Criteria:
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In Tongji hospital
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Neurosurgery | Wuhan | Hubei | 430030 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42129719 | Derived | Zhou M, Nie B, Wu Z, Chen C, Chen H, Zhu M, Li M. Effect of sevoflurane versus propofol on immune inflammation in patients undergoing endovascular coiling of cerebral aneurysm. BMC Anesthesiol. 2026 May 13. doi: 10.1186/s12871-026-03902-z. Online ahead of print. |
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| ID | Term |
|---|---|
| D000777 | Anesthetics |
| D000077149 | Sevoflurane |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D002492 | Central Nervous System Depressants |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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blood
| From enrollment to 3 months postoperation |
| Concentration of interleukin-6 | Test the concentration of interleukin-6 in participants | From enrollment to 3 months postoperation |
| Concentration of interleukin-8 | Test the concentration of interleukin-8 in participants | From enrollment to 3 months postoperation |
| Concentration of tumor necrosis factor | Test the concentration of tumor necrosis factor in participants | From enrollment to 3 months postoperation |
| Concentration of S100B | Test the concentration of S100B in participants | From enrollment to 3 months postoperation |
| length of stay | The time from admission to discharge | through study completion, an average of 6 months |
| costs | Hospitalization expenses | through study completion, an average of 6 months |
| Glasgow Coma Score | The scores are ranging from 3 to 15. And higher scores mean a betterr outcome . | From enrollment to 3 months postoperation |
| D002491 | Central Nervous System Agents |
| D045506 | Therapeutic Uses |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |