Fitness and Nutrition in Glioma

A Pilot Study to Investigate the Effects of Combining a Modified Atkins Diet With a Physical Fitness Regimen in Patients Diagnosed With Malignant Glioma

This is a pilot study assessing the effects of combining a modified Atkins diet with a physical fitness regimen in patients with malignant glioma. A sample size of 15 participants will be enrolled in a 15-week program consisting of two weekly supervised exercise sessions combined with an individualized home exercise program and a modified Atkins diet.

Inclusion Criteria:

• Tissue confirmed diagnosis of high-grade glioma (World Health Organization grade III or IV)
• Karnofsky Performance Status (KPS) ≥ 70%
• Willing to follow the study intervention and follow-up
• Able to give full informed consent

Exclusion Criteria:

• Currently undergoing initial concurrent radiation/chemotherapy
• Severe medical co-morbidities
• Any medical condition which prohibits moderate to vigorous physical activity (60-85% HRmax)
• Any medical condition which prohibits a restrictive diet
• Neurological deficit preventing participation in moderate to vigorous physical activity
• Severe psychiatric illness