Association Between P0.1 and Extubation Failure in Adult Patients With Acute Hypoxemic Respiratory Failure. A Multicenter Prospective Cohort Study

Association Between P0.1 and Extubation Failure in Adult Patients With Acute Hypoxemic Respiratory Failure. A Multicenter Prospective Cohort Study

The goal of this observational study is to learn about the effect of the occlusion pressure during the first 100 miliseconds (P01) over the extubation failure in participants receiving mechanical ventilation for acute respiratory failure.

The main question it aims to answer is:

Are high P0.1 values (≥3 cmH2O) measured 30 minutes after starting a spontaneous breathing trial associated with extubation failure in adult patients who were intubated for acute hypoxemic respiratory failure?

Inclusion Criteria:

• Patients over 17 years of age
• Patients receiving invasive mechanical ventilation for more than 24 hours
• Patients who have been ventilated for acute hypoxemic respiratory failure
• Patients who overcome a PVE
• Patients who, after overcoming the PVE, meet the conditions to be extubated immediately after, according to the team of treating professionals who conduct the weaning
• Patients who are in their first attempt at extubation

Exclusion Criteria:

• Tracheostomized patients
• Patients with neuromuscular disease (For example: Guillain Barré,
• Myasthenia Gravis, Amyotrophic lateral sclerosis, etc.)
• Patients with a decision not to reintubate