To assess EORTC QLQ-C30 mean scale score stratified by age groups and sex.

EORTC QLQ-C30 scales (0-100):

• 5 functional scales (physical, role, emotional, social, and cognitive)

• global health status/QoL scale

  • higher scores indicating better function, QoL

• 3 symptom scales (fatigue, nausea and vomiting, pain)

• 6 single items (dyspnoea, insomnia, appetite loss, constipation, diarrhoea, financial difficulties)

  • higher scores indicating higher level of symptoms

To assess FACIT-Fatigue mean score stratified by age groups and sex. (0 to 52) --> higher scores indicating higher levels of fatigue.

To assess the score of the FACIT item GP5. Item GP5 from the FACIT Measurement System is a summary measure to assess the patient-reported overall impact of treatment toxicity on a 5-point Likert scale, with a higher score indicating higher treatment toxicity.

To compare EORTC QLQ-C30 mean scales scores with a matched case control group of MDS patients.

EORTC QLQ-C30 scales (0-100):

• 5 functional scales (physical, role, emotional, social, and cognitive)

• global health status/QoL scale

  --> higher scores indicating better function, QoL

• 3 symptom scales (fatigue, nausea and vomiting, pain)

• 6 single items (dyspnoea, insomnia, appetite loss, constipation, diarrhoea, financial difficulties)

  • higher scores indicating higher level of symptoms

To compare FACIT-Fatigue mean score with a matched case control group of MDS patients (0 to 52) --> higher scores indicating higher levels of fatigue.