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The purpose of this study is to explore the impact of tumor-associated inflammatory adhesion on the prognosis of colon cancer patients.
In some colon cancer patients, although adhesions between the tumor tissue and surrounding organs are found during surgery, postoperative pathology confirms that the tumor has not directly invaded the adhered organs; instead, the adhesions are caused by tumor-associated inflammation. This condition is defined as tumor-associated inflammatory adhesion.
Currently, the impact of tumor-associated inflammatory adhesion on patient prognosis is still unclear. This study aims to explore the impact of tumor-associated inflammatory adhesion on the prognosis of colon cancer patients through the Surveillance, Epidemiology, and End Results (SEER) and Chinese multi-center databases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| the U.S. National Cancer Center SEER database | SEER*Stat software (version 8.4.3) collected 17 registries cohort data on colon cancer patients between 2010 and 2019. |
| |
| Chinese multi-center database | Chinese multi-center database includes patients from January 2010 to December 2021 at 3 institutions. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| This was a retrospective study and no patient intervention was performed. | Other | This was a retrospective study and no patient intervention was performed. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival time (OS) | OS, defined as the time from the first diagnosis to death from any cause or the last follow-up for surviving patients | up to 10 years |
| Cancer-specific survival time (CSS) | CSS refers to the duration from diagnosis of a tumor until the patient succumbs to the tumor, excluding deaths from other causes. | up to 10 years |
| Recurrence free survival time (RFS) | RFS is the time from the time a patient achieved R0 resection after surgery to the time of recurrence or the end of follow-up. | up to 10 years |
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Inclusion Criteria:
Exclusion Criteria:
1. Patients with distant metastasis, recurrent colon cancer and pT4b CRC were excluded.
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This study utilized the Chinese multi-center database as well as the SEER 17 registries database. The Chinese multi-center database contains data of patients between January 2010 and December 2021, at 3 institutions. SEER*Stat software (version 8.4.1.1) was used for collecting 17 registries cohort data on patients diagnosed with NMIBC between 2010 and 2019.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cancer Hospital Chinese Academy of Medical Sciences | Beijing | Beijing Municipality | 100021 | China |
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| ID | Term |
|---|---|
| D003110 | Colonic Neoplasms |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
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| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |