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Femtosecond laser-assisted cataract surgery is rapidly gaining popularity. Among the 5 femtosecond laser platforms available at present for cataract surgery, the Femto LDV Z8 (Ziemer Ophthalmic Systems AG) is a high-frequency system and delivers energy pulses in nanojoule levels, while Lensx platform (Lensx, Alcon Laboratories, Inc.) used a high-energy laser system. In femtosecond laser-assisted cataract surgery, the laser pretreatment is associated with breakdown of blood-aqueous barrier (BAB) associated with increased aqueous total prostaglandin, cytokines and Oxygen-free radicals concentration. The prostaglandin rise immediately after laser pretreatment is further thought to be the causative factor for the intraoperative miosis in femtosecond laser-assisted cataract surgery. However, the analysis of anterior chamber inflammatory factors, oxidative stress, and pupil size after femtosecond laser-assisted cataract surgery between different laser platforms has not been investigated in clinical studies. Understanding the cytokine and chemokine changes related to the laser pretreatment provides better insight into the inflammatory response in femtosecond laser-assisted cataract surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LenSx | Experimental |
| |
| Z8 | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LenSx | Device | The patients in Group 1 conduct FLACS under LenSx |
| |
| Measure | Description | Time Frame |
|---|---|---|
| PGE2 | The concentrations of PGE2 in aqueous humor | through study completion, an average of half a year |
| cytokines (IL-1β、IL-6, IL-8、TNF-a) | The concentrations of cytokines (IL-1β、IL-6, IL-8、TNF-a) in aqueous humor | through study completion, an average of half a year |
| MDA | The concentrations of MDA in aqueous humor | through study completion, an average of half a year |
| Measure | Description | Time Frame |
|---|---|---|
| central corneal thickness | The central corneal thickness was measured | through study completion, an average of half a year |
| central macular thickness | The central macular thickness was measured |
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Inclusion Criteria:
Age related cataracts over 50 years old, nuclear grades II-III
Exclusion Criteria:
Eye diseases: glaucoma, uveitis
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University | Hangzhou | Zhejiang | 310000 | China |
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| Z8 |
| Device |
The patients in Group 1 conducted FLACS using Z8 |
|
| through study completion, an average of half a year |
| ID | Term |
|---|---|
| D002386 | Cataract |
| D015877 | Miosis |
| ID | Term |
|---|---|
| D007905 | Lens Diseases |
| D005128 | Eye Diseases |
| D011681 | Pupil Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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