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| ID | Type | Description | Link |
|---|---|---|---|
| R56DC016291 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Deafness and Other Communication Disorders (NIDCD) | NIH |
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The goal of this clinical trial is to learn if a speech-language telerehabilitation helps improve communication in people with primary progressive aphasia (PPA), a form of dementia that affects speech and language. The study will also document how acceptable and helpful the program is for both patients and their care partners.
The main questions the study aims to answer are:
Researchers will test the program in a small group of participants to see how people respond. The program includes both speech-language therapy and training for care partners.
Participants will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Multicomponent Lexical Retrieval Training (Multi-LRT) | Experimental |
| |
| Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA) | Experimental |
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| Experimental: Multicomponent Communicaiton Partner Training (Multi-CPT) | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multicomponent Lexical Retrieval Training (Multi-LRT) | Behavioral | In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant target in multiple communication modalities. Treatment focuses on the use of strategies which capitalize on residual linguistic ability and autobiographical memory to support word retrieval. The participant completes two one-hour-long sessions per week plus daily homework. The participant also meets 4 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in script production accuracy | Percent correct intelligible, scripted words for trained/untrained scripts | change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment |
| Change in spoken naming of trained/untrained items | Percent correctly named trained/untrained pictures | change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment |
| Information communicated in any modality for trained/untrained stimuli | Percent of major content units (key words) communicated via speech or nonspeech modalities (e.g., writing, drawing, gesture) for trained/untrained scripts (Multi-VISTA) or words (Multi-LRT) during structured probes and in conversation | change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment |
| Goal Attainment Score | The Goal Attainment Score is self-reported progress on personalized goals based on a five point scale. | change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Change on Quick Aphasia Battery | change on standardized aphasia assessment | change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment |
| Change on Aphasia Impact Questionnaire |
| Measure | Description | Time Frame |
|---|---|---|
| Post-treatment Communication Survey | survey characterizing perceived response to treatment | post-treatment (approximately 6-12 weeks after treatment onset) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Maya L Henry, PhD | University of Texas at Austin | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Texas | Austin | Texas | 78712 | United States |
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| Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA) | Behavioral | In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing personally relevant scripts of 3-5 sentences in length. Length and complexity of scripts are individually tailored. The participant completes 30 minutes per day of home practice, during which they speak in unison with a video/audio model of a healthy speaker clearly articulating the scripts. Biweekly (one hour each) sessions with a clinician are held which target clear and accurate script production, script memorization, and conversational usage of the script and multimodal communication. The participant also meets 6 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies. |
|
| Multicomponent Communication Partner Training (Multi-CPT) | Behavioral | In person or via teletherapy: A multi-component treatment incorporating elements of compensatory and care-partner focused interventions. Biweekly (one hour each) sessions with a clinician are held which target use of communication strategies including multimodal communication for the participant and study partner (e.g., spouse). The participant also completes regular assignments meant to increase generalization of communication strategies and progress on personal goals. |
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change on psychosocial questionnaire for individuals with aphasia
| change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment |
| ID | Term |
|---|---|
| D018888 | Aphasia, Primary Progressive |
| D057180 | Frontotemporal Dementia |
| D008569 | Memory Disorders |
| D057178 | Primary Progressive Nonfluent Aphasia |
| D001037 | Aphasia |
| D019636 | Neurodegenerative Diseases |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D057174 | Frontotemporal Lobar Degeneration |
| D057177 | TDP-43 Proteinopathies |
| D057165 | Proteostasis Deficiencies |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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