Na-Phenylbutyrate VAscular Trial

Na-Phenylbutyrate VAscular Trial

This study will investigate if the drug sodium phenylbutyrate (NaPB) impacts blood pressure and vascular function in healthy volunteers and in patients with diabetes.

Inclusion Criteria:

• Over 18 years of age and less than 60.
• Healthy subjects will have no history of diabetes or prediabetes.
• Diabetes subjects can be either insulin dependent or not.
• Able to provide written consent and to comply with the procedures of the study protocol.

Exclusion Criteria:

• Age <18 or >60
• Pregnant or lactating women.
• Subjects with hypertension or taking any vasodilatory medications, any steroidal drugs, haloperidol, or valproic acid.
• Patients with congestive heart failure, severe renal insufficiency, hepatic failure, or known sodium retention with oedema.
• Active alcohol or substance abuse.
• Use of tobacco within the previous six months.
• Unble to provide written consent and to comply with the procedures of the study protocol.