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This study aims to evaluate the pharmacokinetic/pharmacodynamic drug-drug interactions between DWP16001, DWC202407, and DWC202408 in healthy adults
This study aims to evaluate the pharmacokinetic interactions, pharmacodynamic interactions, safety, and tolerability of DWP16001, DWC202407, and DWC202408 in healthy adults
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Enavogliflozin 0.3mg, once daily | Experimental |
| |
| Metformin 1,000mg, BID | Experimental |
| |
| Glimepiride 2mg, once daily | Experimental |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DWP16001 0.3mg | Drug | 1 tablet, Orally, Once daily single dose |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Cmax,ss of DWP16001 | Peak Plasma Concentration at steady-state | 0-24 hours |
| AUCtau,ss of DWP16001 | Area under the plasma concentration versus time curve at Tau, steady-state | 0-24 hours |
| Cmax,ss of DWC202407 | Peak Plasma Concentration at steady-state | 0-12 hours |
| AUCtau,ss of DWC202407 | Area under the plasma concentration versus time curve at Tau, steady-state | 0-12 hours |
| Cmax,ss of DWC202408 | Peak Plasma Concentration at steady-state | 0-24 hours |
| AUCtau,ss of DWC202408 | Area under the plasma concentration versus time curve at Tau, steady-state | 0-24 hours |
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Inclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| DaYe Jung | Contact | +82-2-550-8317 | dayejung@daewoong.co.kr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | South Korea |
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| ID | Term |
|---|---|
| C000729921 | Enavogliflozin |
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| DWC202407 1,000mg |
| Drug |
1 tablet, Orally, Twice daily |
|
| DWC202408 2mg | Drug | 1 tablet, Orally, Once daily single dose |
|