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Vitamin D, through its action on calcium metabolism, is essential for bone physiology. Vitamin D deficiency can affect muscle function and increase the risk of falls in the elderly, while severe deficiency is common in patients with fragility fractures. Vitamin D and calcium supplementation, in addition to anti-osteoporosis treatment after surgery or conservative treatment, can ensure optimal recovery and survival, especially in patients with a hip fracture.
The goal of vitamin D supplementation is to bring the serum 25-(OH)-D concentration above 30 ng/ml.
Clinical pathways have been developed to support orthopedic surgeons in improving the medical management of patients after orthopedic/surgical fracture management. Pathways include advising primary care physicians and orthopedic surgeons on diagnostic and therapeutic approaches, promoting their appropriate use without compromising quality of care, and educating patients on non-pharmacological management of their disease (physical therapy, lifestyle habits life and nutrition).
This is an observational cohort study that will record data on the use of vitamin D in daily practice in patients with low-energy fractures.
The aim of this study is to measure vitamin D levels in the patient and provide these patients according to daily practice with appropriate supplementation for a period of one year, observing if there is a good functional outcome and a reduction in the risks of new fractures.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1st group: 3 months intake of cholecalciferol supplementation (therapeutic dose) |
| ||
| 2nd group: 3 months therapeutic and 3 months prophylactic dose intake of cholecalciferol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CHOLECALCIFEROL ORAL.SOL 25000 IU/2,5ML | Dietary Supplement | Cholecalciferol 25000IU/week for 3 months in both groups. 2nd group continues with 25000IU/month for following 3 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of Vitamin D levels of the patients after receiving vitamin D supplementation | Measurement of 25(OH)D vitamin | 1 month, 3 months, 6 months and 12 months |
| Evaluation of BMD of the patients after receiving vitamin D supplementation | Measurement of Bone Mineral Density | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| PTH | Measurement of blood test of Parathyroid Hormone | 1 month, 3 months, 6 months and 12 months |
| TSH | Measurement of blood test of Thyroid-stimulating Hormone |
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Inclusion Criteria:
Exclusion Criteria:
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Patients older than 18 years of age with a low energy fracture will be included in the study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Efstathios Chronopoulos, MD, MSc, PhD | Contact | 6944837793 | 0030 | stathi24@yahoo.gr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| KAT General Hospital of Attika | Recruiting | Kifissia | Attica | 14561 | Greece |
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|
| 1 month, 3 months, 6 months and 12 months |
| Ca | Measurement of blood test of Calcium levels | 1 month, 3 months, 6 months and 12 months |
| P | Measurement of blood test of Phosphorus levels | 1 month, 3 months, 6 months and 12 months |
| ALP | Measurement of blood test of Alkaline phosphatase levels | 1 month, 3 months, 6 months and 12 months |
| Al | Measurement of blood test of Albumin levels | 1 month, 3 months, 6 months and 12 months |
| Mg | Measurement of blood test of Magnesium levels | 1 month, 3 months, 6 months and 12 months |
| ID | Term |
|---|---|
| D014808 | Vitamin D Deficiency |
| D010024 | Osteoporosis |
| D006620 | Hip Fractures |
| ID | Term |
|---|---|
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D005264 | Femoral Fractures |
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
| D025981 | Hip Injuries |
| D007869 | Leg Injuries |
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