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| ID | Type | Description | Link |
|---|---|---|---|
| 2/III/HK/2022 | Other Grant/Funding Number | BRIN |
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| Name | Class |
|---|---|
| Andalas University | OTHER |
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Cytochrome P450 2D6 (CYP2D6) is an important enzyme in metabolizing commonly used drugs such as Tramadol hydrochloride (widely used opioid analgesic). Genetic polymorphisms of the CYP2D6 gene have been shown to influence the pharmacodynamic properties of the administered drug. This study aimed to screen 63 postoperative patients (wild-type, CYP2D6*5, and CYP2D6 multiplication) of Minangkabau ethnicity in West Sumatera, Indonesia, who received tramadol using a modified long PCR method and to investigate the clinical impact of tramadol on the patients.
VAS of 63 patients was determined by injecting tramadol at a dose of 100 mg 30 minutes before the operation was completed. It was observed in the recovery room at 30, 60, and 120 minutes. Tramadol had an onset time of 15-60 minutes, with peak effectiveness at 2-6 hours postoperatively. Pain level was categorized into 0 (no pain), 1-3 (signifying mild), 4-6 (middle), and 7-10 ( heavy pain).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Determination of Patients' Visual Analogue Scale (VAS) | Other | Pain level was categorized into 0 (no pain), 1-3 (signifying mild), 4-6 (middle), and 7-10 ( heavy pain). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Post Operative Analgesia | Drug | administering 100 mg of intravenous tramadol 30 minutes before the operation is completed |
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| Measure | Description | Time Frame |
|---|---|---|
| Determination of Patients' Visual Analogue Scale (VAS) | Pain level was categorized into 0 (no pain), 1-3 (signifying mild), 4-6 (middle), and 7-10 ( heavy pain). | . It was observed in the recovery room at 30, 60, and 120 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rsup Dr M Djamil Padang | Padang | West Sumatra | 25129 | Indonesia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41078883 | Derived | Effendi R, Rizqia Haz A, Muhammad Fuad A, Dermawan B, Utami N, Desriani. Distribution of CYP2D6 multiplication, CYP2D6*5, and clinical implications in postoperative patients receiving tramadol analgesia in the Minangkabau ethnic group, Indonesia. F1000Res. 2025 Sep 23;13:1526. doi: 10.12688/f1000research.155988.3. eCollection 2024. |
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VAS of 63 patients was determined by injecting tramadol at a dose of 100 mg 30 minutes before the operation was completed. It was observed in the recovery room at 30, 60, and 120 minutes. Tramadol had an onset time of 15-60 minutes, with peak effectiveness at 2-6 hours postoperatively. Pain level was categorized into 0 (no pain), 1-3 (signifying mild), 4-6 (middle), and 7-10 ( heavy pain).
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| Post Operative Analgesia | Drug | VAS of 63 patients was determined by injecting tramadol at a dose of 100 mg 30 minutes before the operation was completed. It was observed in the recovery room at 30, 60, and 120 minutes. |
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