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| ID | Type | Description | Link |
|---|---|---|---|
| 2024-A02162-45 | Other Identifier | ANSM (IDRCB) |
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| Name | Class |
|---|---|
| University Hospital, Angers | OTHER_GOV |
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The main goal of COCAP is to compare COHb (carboxyhemoglobin) levels measured from venous or arterial samples with those measured from capillary samples in patients suspected of Carbon Monoxide intoxication.Patient participation in the study will be limited to capillary sampling (approx. 5-15 minutes).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study population | The study population must correspond to the research inclusion criteria: Adult patient admitted to the emergency department, presenting with one or more clinical signs (asthenia, headache, nausea, vomiting, loss of consciousness, etc.) and a history compatible with CO intoxication (collective symptoms, notion of smoke, activation of a detector, etc.) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood drop sampling | Diagnostic Test | The process: blood drop sampling Technique: capillary sampling Frequency: Once Time: 5 minutes Sample collection volume: 1mL Total collection volume: 1 mL |
| Measure | Description | Time Frame |
|---|---|---|
| Determine the accuracy of capillary HbCO measurement (compared with venous or arterial HbCO) in patients with suspected CO poisoning. | The main goal will be determined by the mean bias and limits of agreement between capillary and venous (or arterial) sampling (Bland-Altman analysis). | 15 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Determine the diagnostic performance of capillary measurement | Determine the sensitivity, specificity, ROC curve, area under the ROC curve, positive and negative predictive values and likelihood ratios (positive and negative) of capillary measurement for the diagnosis of CO intoxication. The linear correlation coefficient between venous (or arterial) HbCO and capillary HbCO will also be calculated. |
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Inclusion Criteria:
Exclusion Criteria:
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The study population will consist of patients admitted to adult emergency departments with suspected carbon monoxide intoxication.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jules Galy | Contact | 0253482835 | bp-prom-regl@chu-nantes.fr | |
| François JAVAUDIN, MD-Phd | Contact | 33253482835 | francois.javaudin@chu-nantes.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU d'Angers | Recruiting | Angers | Loire-Atlantique | 49100 | France |
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| ID | Term |
|---|---|
| D002249 | Carbon Monoxide Poisoning |
| ID | Term |
|---|---|
| D005739 | Gas Poisoning |
| D011041 | Poisoning |
| D064419 | Chemically-Induced Disorders |
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| 15 minutes |
| Assess the technical difficulties of different blood sampling processes (Measurement of the number of attempts and failure rate for samples) | 15 minutes |
| Assess the technical difficulties of different blood sampling processes (Measurement of the time required to take each sample) | 15 minutes |
| Analyse the technical difficulties associated with the analysis of the two samples (Time between sampling and HbCO result) | 15 minutes |
| Analyse the technical difficulties associated with the analysis of the two samples (percentage of samples that cannot be analysed by the laboratory) | 15 minutes |
| Nantes University Hospital | Recruiting | Nantes | Loire-Atlantique | 44000 | France |
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