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| Name | Class |
|---|---|
| Aga Khan University | OTHER |
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The goal of this observational study is to learn about the long-term effects of maternal multiple micronutrient supplementation from preconception through to lactation on child neurodevelopment and growth in a resource-limited setting where there is a high burden of malnutrition. The main questions it aims to answer are:
This is a cross-sectional follow up study to a substudy of breastmilk composition and infant growth within the Matiari emPowerment and Preconception Supplementation (MaPPS) Trial, wherein mothers were randomized to receive a multiple micronutrient supplement from preconception through to lactation or the standard of care (ClinicalTrials.gov Identifier: NCT04451395).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children born to mothers who received a multiple micronutrient supplement | From preconception to 6-months postpartum, mothers received a multiple micronutrient supplement (oral tablet at UNIMMAP composition [30 mg iron, 400 μg folic acid, 15 mg zinc, 2 mg copper, 65 μg selenium, 800 μg RE vitamin A, 1.4 mg vitamin B1, 1.4 mg vitamin B2, 18 mg niacin, 1.9 mg vitamin B6, 2.6 μg vitamin B12, 70 mg vitamin C, 5 μg vitamin D, 10 mg vitamin E and 150 μg iodine]) | ||
| Children born to mothers who received the standard of care | From preconception to 6-months postpartum, mothers received the standard of care |
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| Measure | Description | Time Frame |
|---|---|---|
| Full scale IQ score | Wechsler Preschool and Primary Scale of Intelligence (WPPSI), minimum score: 40 and maximum score: 160 (higher scores mean a better outcome) | At 4 years of age |
| Measure | Description | Time Frame |
|---|---|---|
| Fine and gross motor skills score | Bruininks-Oseretsky Test of Motor Proficiency, 2nd edition (BOT-2) Brief Form, minimum score: 0 and maximum score: 80 (higher scores mean a better outcome) | At 4 years of age |
| Height |
| Measure | Description | Time Frame |
|---|---|---|
| Weight | At 4 years of age | |
| Middle upper arm circumference | At 4 years of age |
Inclusion Criteria:
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Residence within Matiari District, Pakistan
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aga Khan University | Matiari | Pakistan |
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| ID | Term |
|---|---|
| D044342 | Malnutrition |
| ID | Term |
|---|---|
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| At 4 years of age |
| Head circumference | At 4 years of age |